{"id":103684,"date":"2018-03-11T10:26:22","date_gmt":"2018-03-11T10:26:22","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/atrofia-del-musculo-esqueletico-y-del-tejido-adiposo-en-la-caquexia-inducida-por-la-artritis-experimental-efecto-de-la-administracion-de-acido-eicosapentaenoico-y-de-un-agonista-ppar-alfa\/"},"modified":"2018-03-11T10:26:22","modified_gmt":"2018-03-11T10:26:22","slug":"atrofia-del-musculo-esqueletico-y-del-tejido-adiposo-en-la-caquexia-inducida-por-la-artritis-experimental-efecto-de-la-administracion-de-acido-eicosapentaenoico-y-de-un-agonista-ppar-alfa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/atrofia-del-musculo-esqueletico-y-del-tejido-adiposo-en-la-caquexia-inducida-por-la-artritis-experimental-efecto-de-la-administracion-de-acido-eicosapentaenoico-y-de-un-agonista-ppar-alfa\/","title":{"rendered":"Atrofia del m\u00fasculo esquel\u00e9tico y del tejido adiposo en la caquexia inducida por la artritis experimental : efecto de la administraci\u00f3n de \u00e1cido eicosapentaenoico y de un agonista-ppar alfa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Estibaliz Castillero Olabarria <\/strong><\/h2>\n<p>La artritis experimental es un modelo animal de caquexia inflamatoria. La caquexia es un s\u00edndrome metab\u00f3lico asociado a una enfermedad subyacente que se caracteriza por una respuesta inflamatoria, p\u00e9rdida de peso, atrofia muscular y p\u00e9rdida de masa d e tejido adiposo. En esta tesis se recogen los resultados obtenidos en distintos experimentos que tuvieron como objetivo comprender los mecanismos implicados en la caquexia inducida por la atritit\u00eds experimental. La p\u00e9rdida de masa muscular y de gras a que se producen en la artritis no se deben exclusivamente a la disminuci\u00f3n de la ingesta, ya que estas alteraciones no se producen en las ratas pair fed. En las ratas artr\u00edticas la disminuci\u00f3n de la adipog\u00e9nesis es un factor que contribuye a la dis minuci\u00f3n del tejido adiposo, mientras que la lip\u00f3lisis no aumenta. La atrofia del m\u00fasculo esquel\u00e9tico en la artritis es secundaria a un aumento de la degradaci\u00f3n muscular por el sistema ubiquitina-proteasoma, y no a una disminuci\u00f3n de la miog\u00e9nesis. El tratamiento con \u00e1cido eicosapentaenoico tiene un efecto antiinflamatorio en la artritis experimental, y adem\u00e1s aten\u00faa la atrofia muscular disminuyendo los atrogenes atrogina-1 y murf-1, y aumentando los factores de transcripci\u00f3n que regulan la mio g\u00e9nesis. La artritis experimental disminuye la expresi\u00f3n de los ppar-alfa. La activaci\u00f3n de los ppar-alfa disminuye la inflamaci\u00f3n en la artritis experimental, a la vez que previene en parte la atrofia muscular al disminuir la expresi\u00f3n de los atroge nes y la miostatina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Atrofia del m\u00fasculo esquel\u00e9tico y del tejido adiposo en la caquexia inducida por la artritis experimental : efecto de la administraci\u00f3n de \u00e1cido eicosapentaenoico y de un agonista-ppar alfa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Atrofia del m\u00fasculo esquel\u00e9tico y del tejido adiposo en la caquexia inducida por la artritis experimental : efecto de la administraci\u00f3n de \u00e1cido eicosapentaenoico y de un agonista-ppar alfa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Estibaliz Castillero Olabarria <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/09\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Asuncion Lopez Calderon Barreda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas \u00e1ngel Fern\u00e1ndez-tresguerres hern\u00e1ndez <\/li>\n<li>Mar\u00eda paz Nieto bona (vocal)<\/li>\n<li>beatriz Gal iglesias (vocal)<\/li>\n<li>miriam Granado Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Estibaliz Castillero Olabarria La artritis experimental es un modelo animal de caquexia inflamatoria. La caquexia es un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[5703,99373,209864,4753,209865,129829],"class_list":["post-103684","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-asuncion-lopez-calderon-barreda","tag-beatriz-gal-iglesias","tag-estibaliz-castillero-olabarria","tag-jesus-angel-fernandez-tresguerres-hernandez","tag-maria-paz-nieto-bona","tag-miriam-granado-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/103684","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=103684"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/103684\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=103684"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=103684"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=103684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}