{"id":103743,"date":"2018-03-11T10:26:27","date_gmt":"2018-03-11T10:26:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/association-of-epicardial-adipose-tissue-with-cardiac-alterations-in-the-metabolic-syndrome-a-role-for-cardiotrophin-1\/"},"modified":"2018-03-11T10:26:27","modified_gmt":"2018-03-11T10:26:27","slug":"association-of-epicardial-adipose-tissue-with-cardiac-alterations-in-the-metabolic-syndrome-a-role-for-cardiotrophin-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cardiologia\/association-of-epicardial-adipose-tissue-with-cardiac-alterations-in-the-metabolic-syndrome-a-role-for-cardiotrophin-1\/","title":{"rendered":"Association of epicardial adipose tissue with cardiac alterations in the metabolic syndrome. a role for cardiotrophin-1?"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Mar\u00eda Castellano V\u00e1zquez <\/strong><\/h2>\n<p>El tejido adiposo epic\u00e1rdico es fuente de un conjunto de mediadores proinflamatorios que podr\u00edan contribuir en las alteraciones morfol\u00f3gicas y funcionales t\u00edpicas del s\u00edndrome metab\u00f3lico (sm). La citoquina cardiotrofina-1 (ct-1) induce hipertrofia mioc\u00e1rdica y es producida por el tejido adiposo.   en el presente estudio, se midi\u00f3 mediante ecocardiograf\u00eda la grasa epic\u00e1rdica de 125 pacientes con sm y 125 pacientes control. Se obtuvieron par\u00e1metros ecocardiogr\u00e1ficos de funci\u00f3n y crecimiento ventricular. Los pacientes con sm mostraron incrementos significativos de masa ventricular izquierda (mvi), normalizada por superficie corporal, altura2.7, volumen ventricular as\u00ed como crecimiento inapropiado del vi comparado con los controles. Adem\u00e1s, aquellos pacientes con sm presentaban un patr\u00f3n de relajaci\u00f3n tard\u00eda as\u00ed como presiones de llenado de vi aumentadas. El grosor de grasa epic\u00e1rdica era mayor en pacientes con sm y es notable que exist\u00eda una correlaci\u00f3n significativa con par\u00e1metros de aumento de mvi independientemente de otros factores de confusi\u00f3n. Los niveles de ct-1 circulantes se obtuvieron del suero y se encontr\u00f3 un aumento significativo de ct-1 en los pacientes con sm, que adem\u00e1s se asociaba a par\u00e1metros de incremento de mvi.  la expresi\u00f3n de ct-1 se estudi\u00f3 en biopsias obtenidas de pacientes con sm e hipertrofia ventricular izquierda (hvi) (n=5), sm sin hvi (n=4) as\u00ed como sin sm con lhvi (n=9). Se comprob\u00f3 que la grasa epic\u00e1rdica es fuente de ct-1 tanto a nivel gen\u00e9tico como de prote\u00edna. Ct-1 est\u00e1 presente en diferentes pesos moleculares. Un hallazgo interesante del estudio presente es que los pacientes con sm tienden a expresar niveles m\u00e1s elevados de la forma monom\u00e9rica de la prote\u00edna.  de los resultados del estudio presente se desprende que la ct-1 emerge como un marcador potencial de riesgo cardiometab\u00f3lico en pacientes con sm. Adem\u00e1s, la grasa epic\u00e1rdica es fuente de ct-1, la cual se asocia con crecimiento del vi. As\u00ed, la expresi\u00f3n paracrina de ct-1 por parte de la grasa epic\u00e1rdica adem\u00e1s de la ct-1 circulante de otras fuentes grasas podr\u00eda estar jugando un papel importante en las alteraciones morfol\u00f3gicas y funcionales caracter\u00edsticas del sm.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Association of epicardial adipose tissue with cardiac alterations in the metabolic syndrome. a role for cardiotrophin-1?<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Association of epicardial adipose tissue with cardiac alterations in the metabolic syndrome. a role for cardiotrophin-1? <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Mar\u00eda Castellano V\u00e1zquez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/09\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Javier Diez Martinez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Fern\u00e1ndez avil\u00e9s <\/li>\n<li>Luis Forga llenas (vocal)<\/li>\n<li>joaqu\u00edn Barba cosials (vocal)<\/li>\n<li>alfonso Castro beiras (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Mar\u00eda Castellano V\u00e1zquez El tejido adiposo epic\u00e1rdico es fuente de un conjunto de mediadores proinflamatorios que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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