{"id":103837,"date":"2018-03-11T10:26:32","date_gmt":"2018-03-11T10:26:32","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/control-homeostatico-de-la-liberacion-de-glutamato-por-mglur7\/"},"modified":"2018-03-11T10:26:32","modified_gmt":"2018-03-11T10:26:32","slug":"control-homeostatico-de-la-liberacion-de-glutamato-por-mglur7","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/control-homeostatico-de-la-liberacion-de-glutamato-por-mglur7\/","title":{"rendered":"Control homeost\u00e1tico de la liberaci\u00f3n de glutamato por mglur7"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ricardo Martin Herranz <\/strong><\/h2>\n<p>Control homeost\u00e1tico de la liberaci\u00f3n de glutamato por mglur7.    las sinapsis glutamat\u00e9rgicas est\u00e1n involucradas en procesos de aprendizaje y memoria cerebrales, as\u00ed como en patolog\u00edas cerebrales de curso temporal agudo o m\u00e1s lento, como es el caso de las enfermedades neurodegenerativas. En los botones sin\u00e1pticos, el contenido en receptores presin\u00e1pticos y canales de calcio determina la heterogeneidad en  la probabilidad de liberaci\u00f3n de glutamato. Los receptores metabotr\u00f3picos de glutamato (mg lur) del grupo iii que se expresan en el cerebro (4,7 y 8) se localizan exclusivamente a nivel presin\u00e1ptico donde regulan la liberaci\u00f3n de neurotransmisor. Mglur7, que exhibe baja afinidad por el agonista l-4-amino-fosfonobutirato, l-ap4, inhibe la l iberaci\u00f3n de glutamato por un mecanismo delimitado de membrana que implica la inhibici\u00f3n directa de canales de calcio sin la intervenci\u00f3n de mensajeros difusibles. Esta acci\u00f3n esta mediada por las subunidades ?? De las prote\u00ednas gi\/o y, en la corteza  cerebral, se circunscribe a los terminales que tienen canales de calcio de tipo n. En estos botones sin\u00e1pticos, la reducci\u00f3n de la liberaci\u00f3n de neurotransmisor va paralela a una reducci\u00f3n de la entrada de calcio por un mecanismo insensible a inhibi dores de prote\u00edna quinasa c (pkc), aunque sensible a la activaci\u00f3n de esta quinasa con esteres de forbol.  mglur7 coexiste con otros receptores  metabotr\u00f3picos (gabab y de adenosina a1) en los terminales que expresan canales de calcio n y todos ellos  comparten el mecanismo delimitado de membrana  responsable de la inhibici\u00f3n de la liberaci\u00f3n de neurotransmisor. En este sentido determinamos si la co-expresion de receptores en un bot\u00f3n sin\u00e1ptico esta condicionada por el  tipo de canal de calcio.   la se\u00f1alizaci\u00f3n de mglur7 no se limita a un mecanismo delimitado de membrana. As\u00ed, se ha  descrito la inhibici\u00f3n de canales p\/q som\u00e1ticos por mglur7 recombinantes en c\u00e9lulas granulares de cerebelo. Esta acci\u00f3n, requiere la activaci\u00f3n de fosfolipasa c  (plc) y de pkc. Por otro lado, hay que tener en cuenta que est\u00e1 descrito que la activaci\u00f3n de pkc mediante \u00e9steres de forbol potencia la transmisi\u00f3n sin\u00e1ptica por un incremento en la liberaci\u00f3n del neurotransmisor  y que adem\u00e1s de pkc, los esteres d e forbol tienen  tambien como diana munc-13-1, una prote\u00edna presin\u00e1ptica esencial para la iniciaci\u00f3n de la exocitosis de ves\u00edculas sin\u00e1pticas.    con estos precedentes,  los siguientes objetivos:  1.-  Conocer la posible inhibici\u00f3n por mglur7 de la a<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Control homeost\u00e1tico de la liberaci\u00f3n de glutamato por mglur7<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Control homeost\u00e1tico de la liberaci\u00f3n de glutamato por mglur7 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ricardo Martin Herranz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/09\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>prieto Borja S\u00e1nchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: domingo Triguero robles <\/li>\n<li>laurent Pr\u00e9zeau (vocal)<\/li>\n<li>Jos\u00e9 Antonio Esteban garcia (vocal)<\/li>\n<li>Francisco Ciruela alf\u00e9rez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ricardo Martin Herranz Control homeost\u00e1tico de la liberaci\u00f3n de glutamato por mglur7. las sinapsis glutamat\u00e9rgicas est\u00e1n involucradas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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