{"id":103839,"date":"2018-03-11T10:26:32","date_gmt":"2018-03-11T10:26:32","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-peptido-inhibidor-del-factor-transformante-del-crecimiento-beta-p144a-y-otras-variables-en-un-modelo-de-fibrosis-pericapsular-en-cerdos\/"},"modified":"2018-03-11T10:26:32","modified_gmt":"2018-03-11T10:26:32","slug":"efecto-del-peptido-inhibidor-del-factor-transformante-del-crecimiento-beta-p144a-y-otras-variables-en-un-modelo-de-fibrosis-pericapsular-en-cerdos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cirugia-plastica\/efecto-del-peptido-inhibidor-del-factor-transformante-del-crecimiento-beta-p144a-y-otras-variables-en-un-modelo-de-fibrosis-pericapsular-en-cerdos\/","title":{"rendered":"Efecto del p\u00e9ptido inhibidor del factor transformante del crecimiento beta (p144\u00c2\u00ae) y otras variables en un modelo de fibrosis pericapsular en cerdos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Andrea San Mart\u00edn Maya <\/strong><\/h2>\n<p>La contractura capsular es la complicaci\u00f3n m\u00e1s frecuente tras el aumento mamario. El papel del factor transformante del crecimiento beta (tgf-\u00edY) en el proceso fibr\u00f3tico ha sido demostrado. La inhibici\u00f3n de dicho factor, abre un nuevo camino para el tratamiento de la contractura periprot\u00e9sica. El objetivo de este estudio, es estudiar la reacci\u00f3n fibrosa periprot\u00e9sica atendiendo a la localizaci\u00f3n de los implantes, la superficie de los mismos y la aplicaci\u00f3n de un nuevo p\u00e9ptido inhibidor del tgf- \u00edY (p144). se formaron tres grupos de estudio: 1, implantaci\u00f3n de pr\u00f3tesis mamarias texturadas, con un punto liso en una de sus caras a nivel subcut\u00e1neo y submuscular en cerdos; 2, implantaci\u00f3n de pr\u00f3tesis impregnadas en un veh\u00edculo a base de glicerol; 3, implantaci\u00f3n de las pr\u00f3tesis impregnadas en el veh\u00edculo con el p\u00e9ptido inhibidor diluido en \u00e9l. Los animales fueron sacrificados a las 24 semanas y se extrajeron las c\u00e1psulas para su estudio. los resultados obtenidos mostraron una reducci\u00f3n en el grosor y la cantidad de col\u00e1geno soluble en las c\u00e1psulas de las pr\u00f3tesis en localizaci\u00f3n subcut\u00e1nea respecto a la submuscular y en la porci\u00f3n rugosa de las pr\u00f3tesis contra la porci\u00f3n lisa. No encontramos descenso significativo de estos par\u00e1metros en el grupo tratamiento respecto a los controles. consideramos otros factores como la inflamaci\u00f3n, el hematoma y la influencia del veh\u00edculo sobre la superficie de implante, como cr\u00edticos a la hora de impedir el efecto antifibr\u00f3tico del p\u00e9ptido.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto del p\u00e9ptido inhibidor del factor transformante del crecimiento beta (p144\u00c2\u00ae) y otras variables en un modelo de fibrosis pericapsular en cerdos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto del p\u00e9ptido inhibidor del factor transformante del crecimiento beta (p144\u00c2\u00ae) y otras variables en un modelo de fibrosis pericapsular en cerdos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Andrea San Mart\u00edn Maya <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/09\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Bernardo Hontanilla Calatayud<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: c\u00e9sar Casado p\u00e9rez <\/li>\n<li>Fernando Mart\u00ednez regueira (vocal)<\/li>\n<li>jaume Masia ayala (vocal)<\/li>\n<li>Francisco j. Santos heredero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Andrea San Mart\u00edn Maya La contractura capsular es la complicaci\u00f3n m\u00e1s frecuente tras el aumento mamario. El [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1456,17749],"tags":[210124,29871,37296,89491,195816,147493],"class_list":["post-103839","post","type-post","status-publish","format-standard","hentry","category-cirugia-plastica","category-navarra","tag-andrea-san-martin-maya","tag-bernardo-hontanilla-calatayud","tag-cesar-casado-perez","tag-fernando-Martinez-regueira","tag-francisco-j-santos-heredero","tag-jaume-masia-ayala"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/103839","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=103839"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/103839\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=103839"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=103839"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=103839"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}