{"id":103844,"date":"2018-03-11T10:26:37","date_gmt":"2018-03-11T10:26:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-la-familia-genica-lgi\/"},"modified":"2018-03-11T10:26:37","modified_gmt":"2018-03-11T10:26:37","slug":"caracterizacion-de-la-familia-genica-lgi","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/caracterizacion-de-la-familia-genica-lgi\/","title":{"rendered":"Caracterizaci\u00f3n de la familia g\u00e9nica lgi."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Vicente Herranz P\u00e9rez <\/strong><\/h2>\n<p>La epilepsia lateral temporal de herencia autos\u00f3mica dominante, es una forma de epilepsia parcial, con crisis secundariamente generalizadas, causada por mutaciones en lgi1. Este gen fue inicialmente descrito en 1998 en relaci\u00f3n a la aparici\u00f3n de glioblastomas malignos y se ha visto que su expresi\u00f3n, se relaciona inversamente con el grado de malignidad de estos tumores. El an\u00e1lisis in silico de la secuencia primaria de lgi1, permiti\u00f3 identificar una familia g\u00e9nica compuesta por cuatro elementos, que compart\u00edan una misma organizaci\u00f3n en dominios proteicos: la familia lgi. La existencia de formas cl\u00ednicas de epilepsia similares a aquellas debidas a mutaciones en lgi1 pero sin relaci\u00f3n con este gen, permite establecer la hip\u00f3tesis de que alg\u00fan otro componente de la misma familia g\u00e9nica podr\u00eda estar implicado en la aparici\u00f3n de la enfermedad. Adem\u00e1s, la existencia de varios par\u00e1logos sugiere que se da un cierto grado de redundancia funcional, que podr\u00eda ser explicado por una distinta distribuci\u00f3n anat\u00f3mica de los elementos de la familia lgi. En este trabajo se presentan los resultados del an\u00e1lisis de expresi\u00f3n de los arnm de los componentes de la familia lgi en cerebro de rat\u00f3n adulto. La distribuci\u00f3n de transcritos de los genes de la familia lgi es regionalmente heterog\u00e9nea, lo que hace pensar que desde su origen a partir de un gen ancestral com\u00fan, sufrieron una subfuncionalizaci\u00f3n. Adem\u00e1s, en este trabajo se trata de indagar, en la posible funci\u00f3n o funciones de estos genes.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de la familia g\u00e9nica lgi.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de la familia g\u00e9nica lgi. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Vicente Herranz P\u00e9rez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/09\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jordi Perez Tur<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 manuel Garcia verdugo <\/li>\n<li>adolfo L\u00f3pez de munain arregui (vocal)<\/li>\n<li>beatriz Rico gozalo (vocal)<\/li>\n<li>alino Martinez marcos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vicente Herranz P\u00e9rez La epilepsia lateral temporal de herencia autos\u00f3mica dominante, es una forma de epilepsia parcial, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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