{"id":1040,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/papel-hormonal-en-la-expresion-de-antigenos-hla-en-lineas-celulares-de-cancer-de-mama\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"papel-hormonal-en-la-expresion-de-antigenos-hla-en-lineas-celulares-de-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/papel-hormonal-en-la-expresion-de-antigenos-hla-en-lineas-celulares-de-cancer-de-mama\/","title":{"rendered":"Papel hormonal en la expresion de antigenos hla en lineas celulares de cancer de mama."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Rodriguez Cantalejo <\/strong><\/h2>\n<p>La transcripcion de genes de clase i del hla es controlada por secuencias de adn llamadas elemento regulador de la transcripcion de clase i (cre). La proteina h-2riibp, perteneciente a la familia de los receptores esteroideos, es capaz de unirse tanto al elemento regulador de la respuesta a estrogenos, como al cre. Hemos evaluado la regulacion por estrogenos de la expresion de antigenos de clase i de hla en siete lineas derivadas de cancer de mama, que presentan distintos niveles de re y rp (eia-abbot). Hemos comprobado que el 17-bet estradiol (10-9m) induce expresion de antigenos de clase i en la superficie celular de la linea mcf-7 (hormonodependiente), no encontrandose en las demas lineas (hormonoindependientes) (ifi). La induccion de estos antigenos se relaciona con un incremento de arnm para clase i en mcf-7 (northern blott). El estradiol produce aumento de union de proteinas h-2rii bp a la region ii del cre y disminuye la union de factores nucleares del tipo nfkb\/kbf1 a la region i del cre.  cuando retiramos factores del tipo nfkb\/kbf1 mediante ensayos de preabsorcion, aumenta la union de h-2riibp a cre ii en condiciones basales, hecho dosisdependiente de la concentracion de oligonucleotido no marcado. La sobreexpresion de nfkb\/kbf1 con tnf o pma se correlaciona con una disminucion de la union a cre ii (geles de retardo).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel hormonal en la expresion de antigenos hla en lineas celulares de cancer de mama.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel hormonal en la expresion de antigenos hla en lineas celulares de cancer de mama. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Rodriguez Cantalejo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>cabello  Osuna Ruiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Federico Garrido Torres-puchol <\/li>\n<li>Antonio Alonso Ortiz (vocal)<\/li>\n<li> Molina De Las Infantas Ignacio (vocal)<\/li>\n<li>Manuel Santamar\u00eda Osorio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Rodriguez Cantalejo La transcripcion de genes de clase i del hla es controlada por secuencias de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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