{"id":104038,"date":"2010-01-10T00:00:00","date_gmt":"2010-01-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/contribucion-de-los-microarrays-genomicos-al-diagnostico-y-pronostico-de-los-linfomas-no-hodgkin-de-la%c2%adnea-b\/"},"modified":"2010-01-10T00:00:00","modified_gmt":"2010-01-10T00:00:00","slug":"contribucion-de-los-microarrays-genomicos-al-diagnostico-y-pronostico-de-los-linfomas-no-hodgkin-de-la%c2%adnea-b","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/hematologia\/contribucion-de-los-microarrays-genomicos-al-diagnostico-y-pronostico-de-los-linfomas-no-hodgkin-de-la%c2%adnea-b\/","title":{"rendered":"Contribuci\u00f3n de los microarrays gen\u00f3micos al diagn\u00f3stico y pron\u00f3stico de los linfomas no hodgkin de l\u00ednea b"},"content":{"rendered":"

Tesis doctoral de Cristina Robledo Montero <\/strong><\/h2>\n

Los microarrays-gen\u00f3micos (cgh-arrays) proporcionan una mayor resoluci\u00f3n que las t\u00e9cnicas citogen\u00e9ticas con un mapeo m\u00e1s preciso de las regiones gen\u00f3micas. Se emplearon los cgh-arrays para el estudio de las alteraciones gen\u00f3micas en los lezm y en un grupo de pacientes con ldcgb, ipi alto y tratados homog\u00e9neamente con el esquema del grupo geltamo. Los lezm se han analizado y se han definido nuevas regiones gen\u00f3micas implicadas y se han relacionado los resultados obtenidos con la progresi\u00f3n de la enfermedad. En los ldcgb se han identificado factores gen\u00e9ticos que pueden ser marcadores de la agresividad de la enfermedad. Se estudiaron 68 lezm y 40 ldcgb homog\u00e9neamente tratados. Se realizaron estudios de cgh-arrays con 4 plataformas (bac-array-1mb, 3.500clones; agilent-44k; nimblegen-72k; tiling-array-358k cromosoma7 nimblegen). Los datos se confirmaron con hisf. El 84% de los lezm ten\u00edan alteraciones gen\u00f3micas. Las ganancias afectaron a 4q22.1, 1q21.3(>20%), 6q25.3, 20q13, 3q28(<20%) y las p\u00e9rdidas a 7q, 2q23.3, 17p13(>30%). El tiling-array confirm\u00f3 las p\u00e9rdidas del cromosoma 7 observadas por otras plataformas y describi\u00f3 una nueva regi\u00f3n en 7q22.1(1,51mb). Los resultados se confirmaron por hisf. En el an\u00e1lisis multivariante la edad(<=70a\u00f1os) y las p\u00e9rdidas en 17p13(tp53) mostraron relaci\u00f3n con la progresi\u00f3n(p<.05). El 95% de los ldcgb analizados con cgh-arrays mostraron alteraciones. Los cambios fueron ganancias en 11q23.3, 3p21.1 y 6p21.1(>40%) y p\u00e9rdidas en 5q21.1, 8q23.1(>20%) y 17p13(18%). El estadio avanzado de la enfermedad(p<0.05) se asoci\u00f3 con ganancias en 1p36, 1q21, 3p21, 6p21 y p\u00e9rdidas en 5q21 y las p\u00e9rdidas en 17p con el aumento de ldh. Los enfermos con edad avanzada y p\u00e9rdidas en 10q23.1 o 17p13.2 vivieron menos tiempo(p<0.03). En el an\u00e1lisis univariante se asociaron con la mala respuesta al tratamiento las ganancias en 2p16.1 y p\u00e9rdidas en 17p13.1(tp53) y en el multivariante las ganancias en 2p16.1 (rel\/bcl11a) se asociaron con los pacientes que no respondieron al tratamiento(p=0.02).\n\n\n\n \n\n\n

Datos acad\u00e9micos de la tesis doctoral \u00abContribuci\u00f3n de los microarrays gen\u00f3micos al diagn\u00f3stico y pron\u00f3stico de los linfomas no hodgkin de l\u00ednea b<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Contribuci\u00f3n de los microarrays gen\u00f3micos al diagn\u00f3stico y pron\u00f3stico de los linfomas no hodgkin de l\u00ednea b <\/li>\n
  • Autor:<\/strong>\u00a0 Cristina Robledo Montero <\/li>\n
  • Universidad:<\/strong>\u00a0 Salamanca<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 01\/10\/2010<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Jes\u00fas Mar\u00eda Hernandez Rivas<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: francesc Sol\u00e9 ristol <\/li>\n
        • teresa Flores corral (vocal)<\/li>\n
        • blanca Espinet sol\u00e1 (vocal)<\/li>\n
        • manuela Mollejo villanueva (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Cristina Robledo Montero Los microarrays-gen\u00f3micos (cgh-arrays) proporcionan una mayor resoluci\u00f3n que las t\u00e9cnicas citogen\u00e9ticas con un mapeo […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[15231,218,9386],"tags":[210460,210459,49761,66865,210461,9544],"class_list":["post-104038","post","type-post","status-publish","format-standard","hentry","category-genetica-molecular","category-hematologia","category-salamanca","tag-blanca-espinet-sola","tag-cristina-robledo-montero","tag-francesc-sole-ristol","tag-jesus-maria-hernandez-rivas","tag-manuela-mollejo-villanueva","tag-teresa-flores-corral"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/104038","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=104038"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/104038\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=104038"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=104038"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=104038"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}