{"id":104051,"date":"2010-01-10T00:00:00","date_gmt":"2010-01-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-pravastatina-en-la-disfuncion-endotelial-estres-oxidativo-y-otros-parametros-cardiovasculares\/"},"modified":"2010-01-10T00:00:00","modified_gmt":"2010-01-10T00:00:00","slug":"efectos-de-pravastatina-en-la-disfuncion-endotelial-estres-oxidativo-y-otros-parametros-cardiovasculares","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/evaluacion-de-farmacos\/efectos-de-pravastatina-en-la-disfuncion-endotelial-estres-oxidativo-y-otros-parametros-cardiovasculares\/","title":{"rendered":"Efectos de pravastatina en la disfunci\u00f3n endotelial, estr\u00e9s oxidativo y otros par\u00e1metros cardiovasculares"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Modar Kassan <\/strong><\/h2>\n<p>La pravastatina, usada para disminuir los niveles de colesterol, posee tambi\u00e9n efectos independientes de su acci\u00f3n hipolipemiante. En este trabajo estudiamos los efectos de la administraci\u00f3n de 20 mg\/kg\/d\u00eda de esta estatina, durante cuatro semanas, en ratas con diferente grado de hipertensi\u00f3n (ratas espont\u00e1neamente hipertensas, shr). Pravastatina no tuvo efecto sobre la presi\u00f3n arterial sist\u00f3lica en controles normotensos  (wky), impidi\u00f3 la subida en shr con hipertensi\u00f3n incipiente y la redujo, ligera pero significativamente, en shr con hipertensi\u00f3n establecida. Los niveles de colesterol no se modificaron en ninguno de los grupos. el tratamiento mejor\u00f3 la funci\u00f3n endotelial en arterias de conductancia (aorta) y de resistencia (mesent\u00e9ricas, lecho vascular renal). Este efecto se acompa\u00f1\u00f3 de un incremento en los niveles de  no y en la expresi\u00f3n de enos, y una reducci\u00f3n en la expresi\u00f3n de cox-2.  Adem\u00e1s, amortigu\u00f3 el estado oxidativo generado por la hipertensi\u00f3n reduciendo la producci\u00f3n de aniones super\u00f3xido estimulada por nadph-oxidasa. La valoraci\u00f3n de par\u00e1metros morfo-histol\u00f3gicos indica que el remodelado vascular causado por la hipertensi\u00f3n mejor\u00f3 significativamente tras el tratamiento.  pravastatina redujo la hipertrofia cardiaca, el tama\u00f1o de los cardiomiocitos y la deposici\u00f3n de col\u00e1geno. El an\u00e1lisis de marcadores implicados en los procesos fibr\u00f3ticos indica una reducci\u00f3n en la expresi\u00f3n de col\u00e1geno i, fibronectina y pai-1. experimentos adicionales de funcionalidad y quimiolumiscencia realizados en anillos  de aorta de shr y wistar indican que en la acci\u00f3n antioxidante de pravastatina interviene, adem\u00e1s de la inhibici\u00f3n de la nadph oxidasa, un efecto \u00abscavenger\u00bb. en arterias humanas procedentes de pacientes sometidos a cirug\u00eda de bypass coronario, la incubaci\u00f3n con pravastatina mejor\u00f3 la respuesta endotelio-dependiente y redujo la respuesta a tromboxano y la producci\u00f3n de radicales super\u00f3xido. estos resultados nos indican que pravastatina, independientemente de su efecto hipolipemiante, podr\u00eda resultar beneficiosa en patolog\u00edas cardiovasculares.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de pravastatina en la disfunci\u00f3n endotelial, estr\u00e9s oxidativo y otros par\u00e1metros cardiovasculares<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de pravastatina en la disfunci\u00f3n endotelial, estr\u00e9s oxidativo y otros par\u00e1metros cardiovasculares <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Modar Kassan <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/10\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M\u00aa De Los \u00e1ngeles Sevilla Toral<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Gonz\u00e1lez santos <\/li>\n<li>Juan a Benedi gonzalez (vocal)<\/li>\n<li>catalina Alarcon de la lastra romero (vocal)<\/li>\n<li>Mar\u00eda Jes\u00fas Sanz ferrando (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Modar Kassan La pravastatina, usada para disminuir los niveles de colesterol, posee tambi\u00e9n efectos independientes de su [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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