{"id":104120,"date":"2010-07-10T00:00:00","date_gmt":"2010-07-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-sa%c2%adntesis-y-evaluacion-biologica-de-inhibidores-de-la-deshidroquinasa-tipo-ii-de-conformacion-restringida\/"},"modified":"2010-07-10T00:00:00","modified_gmt":"2010-07-10T00:00:00","slug":"diseno-sa%c2%adntesis-y-evaluacion-biologica-de-inhibidores-de-la-deshidroquinasa-tipo-ii-de-conformacion-restringida","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/santiago-de-compostela\/diseno-sa%c2%adntesis-y-evaluacion-biologica-de-inhibidores-de-la-deshidroquinasa-tipo-ii-de-conformacion-restringida\/","title":{"rendered":"Dise\u00f1o, s\u00edntesis y evaluaci\u00f3n biol\u00f3gica de inhibidores de la deshidroquinasa tipo ii de conformaci\u00f3n restringida"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sonia Mar\u00eda Paz  G\u00f3mez <\/strong><\/h2>\n<p>Este proyecto de tesis doctoral consiste en el desarrollo de nuevos antibi\u00f3ticos, m\u00e1s potentes y selectivos que los del mercado, cuya acci\u00f3n se basa en la inhibici\u00f3n selectiva y eficaz de una ruta metab\u00f3lica existente en las bacterias, la ruta del \u00e1cido siqu\u00edmico, en la que se biosintetiza el \u00e1cido cor\u00edsmico, que es el precursor de los amino\u00e1cidos arom\u00e1ticos y de otros compuestos arom\u00e1ticos importantes como el \u00e1cido f\u00f3lico, las ubiquinonas y ciertas vitaminas. Esta ruta biosint\u00e9tica, adem\u00e1s de estar presente en las bacterias, est\u00e1 presente en los hongos, las plantas y en ciertos par\u00e1sitos como son los causantes de la malaria, por lo que se la considera una fuente importante para el desarrollo de nuevos antibi\u00f3ticos que sean capaces de bloquear determinadas transformaciones enzim\u00e1ticas de esta ruta. Es de esperar que un antibi\u00f3tico que act\u00fae sobre esta ruta metab\u00f3lica muestre una toxicidad m\u00ednima en humanos al no estar presente esta ruta en los animales. Se espera lograr este objetivo mediante la s\u00edntesis de an\u00e1logos con anillos fusionados de 5 miembros (arom\u00e1tico) y de 6 (estructura qu\u00ednica), que permitan fijar la orientaci\u00f3n de los sustituyentes del anillo arom\u00e1tico. De esta manera, se pretenden dirigir, de manera m\u00e1s racional, las interacciones de los grupos funcionales introducidos con el centro activo del enzima. La evaluaci\u00f3n de los derivados que son objeto de este proyecto de tesis doctoral contribuir\u00e1, asimismo, a un conocimiento m\u00e1s detallado de las relaciones estructura-actividad de los enzimas que se pretenden estudiar, las deshidroquinasa tipo ii (mycobacterium tuberculosis, streptomyces coelicolor y helicobacter pylori).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dise\u00f1o, s\u00edntesis y evaluaci\u00f3n biol\u00f3gica de inhibidores de la deshidroquinasa tipo ii de conformaci\u00f3n restringida<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dise\u00f1o, s\u00edntesis y evaluaci\u00f3n biol\u00f3gica de inhibidores de la deshidroquinasa tipo ii de conformaci\u00f3n restringida <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sonia Mar\u00eda Paz  G\u00f3mez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/10\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Concepci\u00f3n Gonz\u00e1lez Bello<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: domingo Dom\u00ednguez Francisco <\/li>\n<li>Mar\u00eda  luz Lopez rodriguez (vocal)<\/li>\n<li>mark johan Van raaij (vocal)<\/li>\n<li>Mar\u00eda Jes\u00fas P\u00e9rez p\u00e9rez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sonia Mar\u00eda Paz G\u00f3mez Este proyecto de tesis doctoral consiste en el desarrollo de nuevos antibi\u00f3ticos, m\u00e1s [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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