{"id":104150,"date":"2010-08-10T00:00:00","date_gmt":"2010-08-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interacciones-de-la-microgla%c2%ada-en-el-cerebelo-de-mama%c2%adferos\/"},"modified":"2010-08-10T00:00:00","modified_gmt":"2010-08-10T00:00:00","slug":"interacciones-de-la-microgla%c2%ada-en-el-cerebelo-de-mama%c2%adferos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/interacciones-de-la-microgla%c2%ada-en-el-cerebelo-de-mama%c2%adferos\/","title":{"rendered":"Interacciones de la microgl\u00edaen el cerebelo de mam\u00edferos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Melissa Lezameta Morgan <\/strong><\/h2>\n<p>La microgl\u00eda ha sido considerada cl\u00e1sicamente como el principal componente del s\u00edstema inmune del cns (s\u00edstema nervioso central), pudiendo presentarse en forma ramificada (inactiva) y forma ameboide (activa). En los \u00faltimos a\u00f1os sin embargo, se viene observando que las funciones de la microgl\u00eda exceden la labor inmune, siendo que este tipo celular participa activamente en ciertos procesos indispensables para el correcto desarrollo y funcionamiento del cns como la muerte neuronal programada y la remodelaci\u00f3n sin\u00e1ptica. Igualmente durante mucho tiempo se ha considerado que la microgl\u00eda en su estado inactivo es una c\u00e9lula quiescente en mayor o menor medida y sin embargo estudios recientes indican que en dicho estado la microgl\u00eda es una c\u00e9lula altamente din\u00e1mica que constantemente emite y retrae prolongaciones que le permiten interaccionar con su ambiente y las c\u00e9lulas de su entorno. En el presente trabajo se observ\u00f3 que la microgl\u00eda interact\u00faa de forma \u00edntima con las neuronas de purkinje durante el desarrollo postnatal del cerebelo de rat\u00f3n. Mediante la utilizaci\u00f3n del cruce f4\/80cre-eyfp, que permite detectar c\u00e9lulas de microgl\u00eda marcadas de forma fluorescente, se observ\u00f3 asimismo el marcaje de un peque\u00f1o porcentaje de neuronas de purkinje. El marcaje de las neuronas de purkinje se debe a la transferencia de la cre recombinasa desde las c\u00e9lulas de microgl\u00eda a las neuronas a trav\u00e9s de un mecanismo dependiente de la polimerizaci\u00f3n de la actina. Esta transferencia ocurre predominantemente durante el periodo de desarrollo postnatal del cerebelo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interacciones de la microgl\u00edaen el cerebelo de mam\u00edferos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interacciones de la microgl\u00edaen el cerebelo de mam\u00edferos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Melissa Lezameta Morgan <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/10\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Manuel Garcia Verdugo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: bernardo Castellano l\u00f3pez <\/li>\n<li>Carlos (secretario) Crespo ruperez (vocal)<\/li>\n<li>ulises G\u00f3mez pinedo (vocal)<\/li>\n<li>enrique Lanuza navarro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Melissa Lezameta Morgan La microgl\u00eda ha sido considerada cl\u00e1sicamente como el principal componente del s\u00edstema inmune del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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