{"id":104412,"date":"2018-03-11T10:27:24","date_gmt":"2018-03-11T10:27:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-polimorfismos-de-genes-reparadores-del-adn-en-cancer-de-mama\/"},"modified":"2018-03-11T10:27:24","modified_gmt":"2018-03-11T10:27:24","slug":"estudio-de-polimorfismos-de-genes-reparadores-del-adn-en-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/estudio-de-polimorfismos-de-genes-reparadores-del-adn-en-cancer-de-mama\/","title":{"rendered":"Estudio de polimorfismos de genes reparadores del adn en cancer de mama"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Castro Marcos <\/strong><\/h2>\n<p>Introducci\u00f3n: la reparaci\u00f3n del adn es un mecanismo fundamental para mantener la integridad del genoma de los individuos y su d\u00e9ficit se ha asociado con diferentes formas de cancer.  Por otro lado, muchos de los tratamientos que se emplean contra estos tumores tumores act\u00faan mediante la inducci\u00f3n directa del da\u00f1o al adn, y la reparaci\u00f3n de estas lesiones se considera uno de los principales mecanismos de resistencia a estos f\u00e1rmacos.   polimorfismos en los genes reparadores del adn que condicionen una disminuci\u00f3n de su funci\u00f3n se han asociado tanto al riesgo de cancer de mama (cm) como a la respuesta a diferentes formas de tratamiento. objetivos: analizar la relaci\u00f3n de xrcc3thr241met, xrcc1arg399gln y xpdlys751gln con el riesgo de cancer de mama, la edad al diagnostico y la respuesta al tratamiento. m\u00e9todos: se realizo un estudio de asociaci\u00f3n de casos y controles, e independientemente, un estudio f\u00e1rmaco y radio-gen\u00f3mico. Se incluyeron 174 mujeres con cm y 300 controles. El genotipado del adn germinal se realizo mediante pcr-rflp y q-pcr.  resultados: el alelo gln de xrcc1arg399gln fue m\u00e1s  frecuente entre los casos que en los controles, asoci\u00e1ndose a un incremento del  riesgo de cm (p=0.002, or:1.96. Ic95%1.3-3).   los alelos que presentan mejor capacidad de reparaci\u00f3n se asociaron al diagn\u00f3stico de cm a edades m\u00e1s tard\u00edas, pero la diferencia solo fue estad\u00edsticamente significativa para xpd751lys\/lys.  ninguno de los polimorfismos se asoci\u00f3 con la toxicidad cut\u00e1nea aguda o cr\u00f3nica tras rt xrcc1399arg\/arg y xrcc3241met\/met se asociaron a mejor supervivencia libre de enfermedad (p=0.007, hr: 0.4, ic95%0.2-0.9) y supervivencia global (p=0.027, hr:0.15, ic95% 0.02-0.99) respectivamente, en pacientes con cm en estadio precoz tratadas con antraciclinas. conclusiones:  xrcc1399gln se asocia con el riesgo de cm. Xpd751lys\/lys, se asocia con el diagn\u00f3stico de cm a edades m\u00e1s tard\u00edas . Xrcc3thr241met y xrcc1arg399gln podr\u00edan implicaciones farmacogenomicas para seleccionar el tratamiento m\u00e1s adecuado para las pacientes con cm en estadios precoces.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de polimorfismos de genes reparadores del adn en cancer de mama<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de polimorfismos de genes reparadores del adn en cancer de mama <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Castro Marcos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/10\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Jes\u00fas Cruz Hern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alberto Gomez alonso <\/li>\n<li>ignacio Blanco guillermo (vocal)<\/li>\n<li>rosalind Eeles (vocal)<\/li>\n<li>Jes\u00fas Garc\u00eda mata (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Castro Marcos Introducci\u00f3n: la reparaci\u00f3n del adn es un mecanismo fundamental para mantener la integridad del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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