{"id":104485,"date":"2018-03-11T10:27:29","date_gmt":"2018-03-11T10:27:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/funcion-de-genes-reguladores-de-la-subfamilia-lal-large-atp-binding-regulators-of-the-luxr-family-de-streptomyces-coelicolor-en-la-produccion-de-metabolitos-secundarios\/"},"modified":"2018-03-11T10:27:29","modified_gmt":"2018-03-11T10:27:29","slug":"funcion-de-genes-reguladores-de-la-subfamilia-lal-large-atp-binding-regulators-of-the-luxr-family-de-streptomyces-coelicolor-en-la-produccion-de-metabolitos-secundarios","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/antibioticos\/funcion-de-genes-reguladores-de-la-subfamilia-lal-large-atp-binding-regulators-of-the-luxr-family-de-streptomyces-coelicolor-en-la-produccion-de-metabolitos-secundarios\/","title":{"rendered":"Funci\u00f3n de genes reguladores de la subfamilia lal (large atp-binding regulators of the luxr family) de streptomyces coelicolor  en la producci\u00f3n de metabolitos secundarios"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana Mart\u00ednez Guerra <\/strong><\/h2>\n<p>Los reguladores lal (large atp-binding regulators of the luxr family) constituyen una subfamilia de reguladores transcripcionales poco estudiados.  Algunos reguladores de este tipo han sido identificados dentro de agrupaciones de genes que codifican antibi\u00f3ticos y otros metabolitos secundarios de actinomicetos, por lo que han sido tradicionalmente considerados reguladores espec\u00edficos de ruta. Sin embargo, estudios realizados en nuestro laboratorio han revelado su implicaci\u00f3n no s\u00f3lo en la regulaci\u00f3n de la bios\u00edntesis de antibi\u00f3ticos, sino tambi\u00e9n en pasos superiores de las cascadas de regulaci\u00f3n, actuando de un modo pleiotr\u00f3pico.    en este estudio se han inactivado cinco genes lal de streptomyces coelicolor: sco0877, sco6334, sco7093, sco7143 y sco7173 observ\u00e1ndose, en algunos casos, la alteraci\u00f3n de la producci\u00f3n de antibi\u00f3ticos. Se han usado micromatrices de adn y pcr cuantitativa para examinar el transcriptoma de los mutantes d0877 y d7173 en comparaci\u00f3n con el obtenido en la cepa parental s. Coelicolor m145. Nuestros resultados indican que los reguladores estudiados lal 0877 y lal 7173 act\u00faan de una forma global, afectando a varios procesos celulares, entre los que se encuentran la respuesta a la escasez de fosfato y la bios\u00edntesis del antibi\u00f3tico pigmentado actinorrodina. Esta es la primera vez que se lleva a cabo un an\u00e1lisis funcional de este tipo de reguladores transcripcionales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Funci\u00f3n de genes reguladores de la subfamilia lal (large atp-binding regulators of the luxr family) de streptomyces coelicolor  en la producci\u00f3n de metabolitos secundarios<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Funci\u00f3n de genes reguladores de la subfamilia lal (large atp-binding regulators of the luxr family) de streptomyces coelicolor  en la producci\u00f3n de metabolitos secundarios <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana Mart\u00ednez Guerra <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/10\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Francisco Mart\u00edn Mart\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas manuel Cantoral fern\u00e1ndez <\/li>\n<li>Marta Vaz  mendes (vocal)<\/li>\n<li>Jos\u00e9 Luis Barredo fuente (vocal)<\/li>\n<li>margarita Mar\u00eda D\u00edaz mart\u00ednez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana Mart\u00ednez Guerra Los reguladores lal (large atp-binding regulators of the luxr family) constituyen una subfamilia de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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