{"id":104550,"date":"2018-03-11T10:27:35","date_gmt":"2018-03-11T10:27:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-fosforilacion-y-la-simoilacion-en-la-proteccion-frente-al-envejecimiento-y-el-cancer\/"},"modified":"2018-03-11T10:27:35","modified_gmt":"2018-03-11T10:27:35","slug":"la-fosforilacion-y-la-simoilacion-en-la-proteccion-frente-al-envejecimiento-y-el-cancer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/la-fosforilacion-y-la-simoilacion-en-la-proteccion-frente-al-envejecimiento-y-el-cancer\/","title":{"rendered":"La fosforilaci\u00f3n y la simoilaci\u00f3n en la protecci\u00f3n frente al envejecimiento y el c\u00e1ncer"},"content":{"rendered":"

Tesis doctoral de Paula Gutierrez Martinez <\/strong><\/h2>\n

During lifetime, dna encounters many types of damage, both from endogenous and%&\/exogenous sources. Most lesions are detected and repaired without compromising the life of the%&\/cells. However, there are special types of damage that constitute a threat to the integrity of the%&\/genome. Double strand breaks (dsb) are the most deleterious lesions that dna can suffer. On%&\/one hand, broken dna is a potential source of mutations and chromosomal rearrangements,%&\/which can lead to the development of cancer. On the other hand, and if the amount of damage is%&\/over a certain threshold, cells can activate apoptotic and\/or senescence programs, which can%&\/compromise the regenerative ability of tissues and lead to ageing related pathologies. So, the%&\/integrity of the genome is a crucial event in the life of every cell. However, unlike proteins and%&\/other \u00c2\u00bflife molecules\u00c2\u00bf, dna is not replaced. Thus, proper detection of dna damage, precise%&\/signaling and potent repair machineries are needed. The response that cells establish upon dna%&\/damage is what we call the dna damage response (ddr). Protein kinases such as atm and%&\/atr are key activators of this transduction pathway. Despite their differences, both share the same%&\/objective: start a phosphorylation cascade in order to establish the g1\/s, intras and g2\/m%&\/checkpoints, which allow the cell time for repair. However, there is evidence that transduction%&\/cascades besides phosphorylation are also triggered by the lesion. Accordingly, it is becoming%&\/increasingly clear that other posttranslational modifications are crucial for proper maintenance of%&\/genomic integrity. Using different mouse models and approaches, we have investigated the role of%&\/two signaling pathways \u00c2\u00bfphosphorylation and sumoylation- in the maintenance of genomic%&\/integrity. Regarding phosphorylation, we have studied the role of chk1, atr\u00c2\u00bfs main effector%&\/kinase, in the response to replicative stress (rs), a poorly understood type of damage that arises%&\/from every replication. Regarding sumoylation, we have studied the role of a novel e3 sumo%&\/ligase known as mms21 which was thought to be involved in homologous recombination (hr)%&\/repair, but which was completely unexplored in mammalian systems. Briefly, we have demonstrated%&\/that a third copy of the chk1 gene can protect from the ageing caused by rs in a mouse model of%&\/the seckel syndrome. In addition, we present the first evidence to show that the genome protection%&\/provided by the mms21\/smc5\/smc6 complex protects from tumor development in mammals.%&\/Altogether, this work offer novel insights about how the signaling of dna damage \u00c2\u00bfby%&\/phosphorylation or sumoylation- impacts of the onset of ageing and\/or cancer.<\/p>\n

 <\/p>\n

Datos acad\u00e9micos de la tesis doctoral \u00abLa fosforilaci\u00f3n y la simoilaci\u00f3n en la protecci\u00f3n frente al envejecimiento y el c\u00e1ncer<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 La fosforilaci\u00f3n y la simoilaci\u00f3n en la protecci\u00f3n frente al envejecimiento y el c\u00e1ncer <\/li>\n
  • Autor:<\/strong>\u00a0 Paula Gutierrez Martinez <\/li>\n
  • Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 28\/10\/2010<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • capetillo Ruiz Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: andr\u00e9s Aguilera l\u00f3pez <\/li>\n
        • Ana Losada valiente (vocal)<\/li>\n
        • jordi Torres rosell (vocal)<\/li>\n
        • Manuel Serrano marug\u00e1n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Paula Gutierrez Martinez During lifetime, dna encounters many types of damage, both from endogenous and%&\/exogenous sources. Most […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,160],"tags":[29954,10985,198397,59531,41977,211262],"class_list":["post-104550","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-bioquimica","tag-ana-losada-valiente","tag-andres-aguilera-lopez","tag-capetillo-ruiz-fernandez","tag-jordi-torres-rosell","tag-manuel-serrano-marugan","tag-paula-gutierrez-Martinez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/104550","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=104550"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/104550\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=104550"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=104550"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=104550"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}