{"id":104579,"date":"2018-03-11T10:27:39","date_gmt":"2018-03-11T10:27:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-localizacion-subcelular-de-la-protea%c2%adna-humana-noa36-y-de-su-relacion-con-la-apoptosis\/"},"modified":"2018-03-11T10:27:39","modified_gmt":"2018-03-11T10:27:39","slug":"estudio-de-la-localizacion-subcelular-de-la-protea%c2%adna-humana-noa36-y-de-su-relacion-con-la-apoptosis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cadiz\/estudio-de-la-localizacion-subcelular-de-la-protea%c2%adna-humana-noa36-y-de-su-relacion-con-la-apoptosis\/","title":{"rendered":"Estudio de la localizaci\u00f3n subcelular de la prote\u00edna humana noa36 y de su relaci\u00f3n con la  apoptosis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ivan S\u00e1nchez  De Melo <\/strong><\/h2>\n<p>En este trabajo se ha caracterizado funcional y estructuralmente el autoant\u00edgeno humano noa36. Los resultados del mismo han descrito una disminucion de la sensibilidad de celulas hela silenciadas para la prote\u00edna noa36 frente al estres genot\u00f3xico, ademas se ha determinado el caracter proapopt\u00f3tico de la prote\u00edna noa36 y su migraci\u00f3n desde la mitocondria hasta el citoplasma durante la activaci\u00f3n principalmente de la v\u00eda interna de la apoptosis. Por otro lado se ha determinado que esta proteina no interacciona con bcl-2, bcl-x, mcl-1, bax, bak, bid y bim. Tambi\u00e9n se ha identificado el dominio responsable de la muerte celular inducida por noa36 en celulas hela y se ha descrito la existencia de un se\u00f1al de localizaci\u00f3n nucleolar en el dominio amino-terminal de la prote\u00edna dentro del cual los amino\u00e1cidos situados en posicion 3, 4 y 5 son cr\u00edticos para la capacidad se\u00f1alizadora.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la localizaci\u00f3n subcelular de la prote\u00edna humana noa36 y de su relaci\u00f3n con la  apoptosis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la localizaci\u00f3n subcelular de la prote\u00edna humana noa36 y de su relaci\u00f3n con la  apoptosis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ivan S\u00e1nchez  De Melo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00e1diz<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/10\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jorge Bol\u00edvar P\u00e9rez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  pedro Mart\u00ednez barbera <\/li>\n<li>carmen Segundo iglesias (vocal)<\/li>\n<li>esther Caparr\u00f3s cayuela (vocal)<\/li>\n<li>Carlos Pendon melendez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ivan S\u00e1nchez De Melo En este trabajo se ha caracterizado funcional y estructuralmente el autoant\u00edgeno humano noa36. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,1506],"tags":[211306,123468,165578,211305,91297,209084],"class_list":["post-104579","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-cadiz","tag-carlos-pendon-melendez","tag-carmen-segundo-iglesias","tag-esther-caparros-cayuela","tag-ivan-sanchez-de-melo","tag-jorge-bolivar-perez","tag-juan-pedro-Martinez-barbera"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/104579","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=104579"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/104579\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=104579"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=104579"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=104579"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}