{"id":104593,"date":"2018-03-11T10:27:39","date_gmt":"2018-03-11T10:27:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/rutas-de-glicosilacion-en-candida-albicans-circuitos-reguladores-y-efectos-sobre-virulencia\/"},"modified":"2018-03-11T10:27:39","modified_gmt":"2018-03-11T10:27:39","slug":"rutas-de-glicosilacion-en-candida-albicans-circuitos-reguladores-y-efectos-sobre-virulencia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/microbiologia\/rutas-de-glicosilacion-en-candida-albicans-circuitos-reguladores-y-efectos-sobre-virulencia\/","title":{"rendered":"Rutas de glicosilaci\u00f3n en candida albicans: circuitos reguladores y efectos sobre virulencia"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Del Pilar Dom\u00ednguez Cantero <\/strong><\/h2>\n<p>Las prote\u00ednas o-manosiltransferasas catalizan la adici\u00f3n de la primera mol\u00e9cula de manosa a prote\u00ednas secretadas. Cinco isoformas (pmt1, pmt2, pmt4, pmt5 y pmt6) se han identificado en candida albicans. En este trabajo se ha estudiado la regulaci\u00f3n de los genes pmt a nivel de transcripci\u00f3n y del promotor. Adem\u00e1s se identificaron rutas de se\u00f1alizaci\u00f3n que detectan y transmiten los defectos en la o-glicosilaci\u00f3n.  la deleci\u00f3n de los genes pmt individualmente produjo cambios en la expresi\u00f3n de los restantes genes pmt. Se detect\u00f3 un incremento en la expresi\u00f3n de pmt2 en el mutante pmt1 y una sobreexpresi\u00f3n del transcrito de pmt4 en la cepa heterocig\u00f3tica pmt2\/pmt2. En presencia de inhibidores de la pared celular y de glicosilaci\u00f3n, del mismo modo que en los correspondientes mutantes, se observ\u00f3 un incremento del transcrito de pmt1. el gen pmt1 es regulado a nivel de la regi\u00f3n promotora por defectos de la pared celular. Los genes pmt2 y pmt4 presentan aguas arriba regiones interg\u00e9nicas muy cortas (333 y 369 bp, respectivamente). No se observ\u00f3 una regulaci\u00f3n para las construcciones de los promotores de pmt2 y pmt4. Por tanto ambos genes parecen estar regulados a nivel postranscripcional. los resultados muestran que las rutas de se\u00f1alizaci\u00f3n del sensor msb2, la mapk cek1, calcineurina y el factor de transcripci\u00f3n ace2 regulan la respuesta a una o-manosilaci\u00f3n defectuosa y la expresi\u00f3n de los genes pmt. Los datos obtenidos indican que msb2, cek1 y ace2 reprimen la expresi\u00f3n de pmt1 si la n-glicosilaci\u00f3n se encuentra intacta. Las tres prote\u00ednas son necesarias para la expresi\u00f3n basal de pmt2 y pmt4 y para su expresi\u00f3n en respuesta a la inhibici\u00f3n de pmt1. La ruta de la calcineurina reprime la expresi\u00f3n de pmt1, mientras que tambi\u00e9n es necesaria para la expresi\u00f3n de los genes pmt2 y pmt4.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Rutas de glicosilaci\u00f3n en candida albicans: circuitos reguladores y efectos sobre virulencia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Rutas de glicosilaci\u00f3n en candida albicans: circuitos reguladores y efectos sobre virulencia <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Del Pilar Dom\u00ednguez Cantero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/10\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>\u00e1ngel Dom\u00ednguez Olavarri<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joachim F. ernst <\/li>\n<li>Carlos Gancedo rodr\u00edguez (vocal)<\/li>\n<li>germ\u00e1n Larriba calle (vocal)<\/li>\n<li>vlada Urlacher (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Del Pilar Dom\u00ednguez Cantero Las prote\u00ednas o-manosiltransferasas catalizan la adici\u00f3n de la primera mol\u00e9cula de manosa [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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