{"id":104594,"date":"2018-03-11T10:27:39","date_gmt":"2018-03-11T10:27:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-interaccion-de-la-calmodulina-con-los-canales-kcnq2\/"},"modified":"2018-03-11T10:27:39","modified_gmt":"2018-03-11T10:27:39","slug":"estudio-de-la-interaccion-de-la-calmodulina-con-los-canales-kcnq2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/proteinas\/estudio-de-la-interaccion-de-la-calmodulina-con-los-canales-kcnq2\/","title":{"rendered":"Estudio de la interacci\u00f3n de la calmodulina con los canales kcnq2"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alessandro Alaimo <\/strong><\/h2>\n<p>La corriente m desempe\u00f1a un papel importante en el control de la excitabilidad neuronal. Es una corriente activa por debajo del umbral de disparo de potenciales de acci\u00f3n y act\u00faa como freno inhibitorio que contrarresta la excitaci\u00f3n de la neurona, devolvi\u00e9ndola a su estado de reposo.  el substrato molecular de  la corriente m son los canales selectivos al potasio de la familia kcnq (kv7). Mutaciones en cuatro de sus cinco miembros (kv7.1-kv7.5) se asocian a enfermedades autos\u00f3micas dominantes. Algunas mutaciones en las subunidades neuronales kcnq2 o kcnq3 se han visto implicadas un s\u00edndrome epil\u00e9ptico conocido como convulsiones neonatales familiares benignas (bfnc).  la regi\u00f3n c-terminal intracelular de estos canales presenta varios dominios de regulaci\u00f3n de prote\u00ednas y l\u00edpidos. En particular dos h\u00e9lices \u00c2\u00bf (h\u00e9lices a y b) presentes en esta regi\u00f3n forman un dominio discontinuo que une la prote\u00edna calmodulina. La importancia funcional de tal interacci\u00f3n todav\u00eda esta poco estudiada pero hay evidencias que demuestran que es trascendental para el correcto funcionamiento de los canales.  el objetivo de este trabajo de tesis doctoral ha sido la caracterizaci\u00f3n bioqu\u00edmica de la interacci\u00f3n entre la calmodulina y los canales kcnq2, analizando los aspectos m\u00e1s relevantes que pueden afectar a tal interacci\u00f3n como los niveles de ca2+ y la presencia de mutaciones en el canal. Adem\u00e1s hemos podido determinar cuales regiones, tanto en el canal como en la calmodulina, son importantes para la interacci\u00f3n de estas dos prote\u00ednas. Finalmente, a la luz de los resultados obtenidos, se propone un posible papel funcional de la asociaci\u00f3n kcnq2- calmodulina, siendo esta prote\u00edna necesaria para el correcto transporte de los canales a la membrana plasm\u00e1tica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la interacci\u00f3n de la calmodulina con los canales kcnq2<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la interacci\u00f3n de la calmodulina con los canales kcnq2 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alessandro Alaimo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/10\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>\u00e1lvaro Villaroel Mu\u00f1oz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alicia Alonso izquierdo <\/li>\n<li>Antonio Villalobo polo (vocal)<\/li>\n<li>Jos\u00e9 Manuel Gonzalez ros (vocal)<\/li>\n<li>pilar De la pe\u00f1a cortines (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alessandro Alaimo La corriente m desempe\u00f1a un papel importante en el control de la excitabilidad neuronal. Es [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[12909,3178],"tags":[211336,13242,64051,14580,24267,94089],"class_list":["post-104594","post","type-post","status-publish","format-standard","hentry","category-pais-vasco-euskal-herriko-unibertsitatea","category-proteinas","tag-alessandro-alaimo","tag-alicia-alonso-izquierdo","tag-alvaro-villaroel-munoz","tag-antonio-villalobo-polo","tag-jose-manuel-gonzalez-ros","tag-pilar-de-la-pena-cortines"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/104594","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=104594"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/104594\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=104594"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=104594"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=104594"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}