{"id":10466,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1996\/01\/01\/investigacion-de-la-funcion-de-la-celula-beta-y-de-la-sensibilidad-periferica-a-la-insulina-en-la-hipertension-arterial-esencial\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"investigacion-de-la-funcion-de-la-celula-beta-y-de-la-sensibilidad-periferica-a-la-insulina-en-la-hipertension-arterial-esencial","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/investigacion-de-la-funcion-de-la-celula-beta-y-de-la-sensibilidad-periferica-a-la-insulina-en-la-hipertension-arterial-esencial\/","title":{"rendered":"Investigacion de la funcion de la celula beta y de la sensibilidad periferica a la insulina en la hipertension arterial esencial."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garcia Estevez Daniel Apolinar <\/strong><\/h2>\n<p>El proposito de esta tesis doctoral fue triple: 1) estudiar la presencia de resistencia a la insulina (ri) y grado de la misma en la hipertension arterial esencial (htae) ligera\/moderada en el hipertenso en normopeso y obesidad (ob), 2) investigar la presencia de ri en los estadios prehipertensivos, y 3) valorar la influencia del tratamiento antihipertensivo con antagonistas del calcio (nitrendipino, ditiazem) y con un ieca (quinaprilo) sobre el metabolismo de la glucosa y el perfil lipidico.  sujetos y metodos: estudiamos tres grupos de pacientes:  i) 15 pacientes con hta e sin ob, sin intolerancia a la glucosa (itg), sin microalbuminuria, sin dislipemias y sin antecedentes familiares de dmndi, 2) 12 familiares en primer grado de pacientes con htae (fhtae), y 3) 37 pacientes obesos con htae (ob\/htae). Como grupos controles se emplearon 23 sujetos sanos y 17 pacientes con obesidad no complicada. En todos los grupos se valoro la sensibilidad tisular a la insulina (sl, 10-4 min-1 (uu\/ml)-1 (uu\/ml)-1, la metabolizacion de la glucosa \u00abper se\u00bb (sg, 10-1 mi-1 min-1), y la sensibilidad de la celula beta a la glucosa durante la primera y segunda fases de secrecion de la insulina (01, 02); empleando el modelo minimo del metabolismo de la glucosa y de la cinetica de la insulina. Doce pacientes fueron tratados con nitrendipino (20 mg\/ d\/ 12 semanas), 20 con diltiazem (360 mg\/ d\/ 12 semanas) t 17 con quinapril (20 mg\/ d\/ 12 semanas), y los parametros metabolicos fueron nuevamente valorados. Para el analisis estadistico se emplearon test parametricos y no parametricos segun fue apropiado, y se realizo un analisis de la covarianza usando la edad y el bmi como variables. Resultaods. No hemos observado diferencias significativas en los parametros metabolicos analizados (si, sg, 0i, 02, secrecion de insulina) entre los grupos de estudio (fhtae, htae sin ob\/hitae) y sus respectivos controles. Los valores de la si fueron: fhtae vs control, 7.31+-5.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Investigacion de la funcion de la celula beta y de la sensibilidad periferica a la insulina en la hipertension arterial esencial.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Investigacion de la funcion de la celula beta y de la sensibilidad periferica a la insulina en la hipertension arterial esencial. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garcia Estevez Daniel Apolinar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Cabezas Cerrato<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Emilio Barrio Gomez <\/li>\n<li>Luis Felipe Pallardo Sanchez (vocal)<\/li>\n<li>Jos\u00e9 Ram\u00f3n Gonz\u00e1lez Juan atey (vocal)<\/li>\n<li>Jos\u00e9 Antonio Amado Se\u00f1aris (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garcia Estevez Daniel Apolinar El proposito de esta tesis doctoral fue triple: 1) estudiar la presencia de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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