{"id":104666,"date":"2010-04-11T00:00:00","date_gmt":"2010-04-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-inhibidores-de-la-proteasa-del-vih-en-la-adherencia-y-otros-determinantes-de-patogenicidad-de-candida-albicans-y-candida-dubliniensis\/"},"modified":"2010-04-11T00:00:00","modified_gmt":"2010-04-11T00:00:00","slug":"efecto-de-inhibidores-de-la-proteasa-del-vih-en-la-adherencia-y-otros-determinantes-de-patogenicidad-de-candida-albicans-y-candida-dubliniensis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/microbiologia-clinica\/efecto-de-inhibidores-de-la-proteasa-del-vih-en-la-adherencia-y-otros-determinantes-de-patogenicidad-de-candida-albicans-y-candida-dubliniensis\/","title":{"rendered":"Efecto de inhibidores de la proteasa del vih en la adherencia y otros determinantes de patogenicidad de candida albicans y candida dubliniensis"},"content":{"rendered":"

Tesis doctoral de Leopoldo Lucio Mero <\/strong><\/h2>\n

Candida albicans y candida dubliniensis son dos pat\u00f3genos oportunistas que pueden producir infecci\u00f3n en pacientes inmunodeprimidos como enfermos de sida, produciendo, entre otros cuadros cl\u00ednicos, candidiasis orofar\u00edngea. Entre los factores de virulencia de c. Albicans y c. Dubliniensis cabe destacar la producci\u00f3n de aspartilproteasas, el dimorfismo, la hidrofobicidad de la superficie celular (hsc), la capacidad de adherencia a pl\u00e1stico y a c\u00e9lulas. el objetivo de esta tesis fue estudiar los factores de virulencia de c. Albicans y c. Dubliniensis y su posible modificaci\u00f3n por los inhibidores de la proteasa del vih (ip-vih), concretamente ritonavir y saquinavir. se ha estudiado el efecto de ritonavir y saquinavir sobre: –\tla cin\u00e9tica de crecimiento y actividad proteol\u00edtica de c. Albicans y c. Dubliniensis. –\tsobre la hsc y capacidad de adherencia a pl\u00e1stico de las mismas. –\tsobre su capacidad de adherencia a c\u00e9lulas epiteliales bucales (ceb) –\t los resultados obtenidos muestran que los ip-vih: –\tinhiben la actividad proteol\u00edtica de c. Albicans y c. Dubliniensis e inhiben su crecimiento en medio con alb\u00famina como fuente de nitr\u00f3geno (ycb-bsa). –\tdisminuyen su hsc en un grado variable que depende del medio de cultivo. –\tdisminuyen la capacidad de adherencia a pl\u00e1stico de las mismas, fundamentalmente saquinavir en medio ycb-bsa a 22\u00c2\u00bac. –\tritonavir disminuye la capacidad de adherencia a ceb de c. Albicans y estimula la adherencia a ceb de c. Dubliniensis. –\tsaquinavir, a la concentraci\u00f3n estudiada, no modifica la capacidad de adherencia a ceb ni de c. Albicans ni de c. Dubliniensis.<\/p>\n

 <\/p>\n

Datos acad\u00e9micos de la tesis doctoral \u00abEfecto de inhibidores de la proteasa del vih en la adherencia y otros determinantes de patogenicidad de candida albicans y candida dubliniensis<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de inhibidores de la proteasa del vih en la adherencia y otros determinantes de patogenicidad de candida albicans y candida dubliniensis <\/li>\n
  • Autor:<\/strong>\u00a0 Leopoldo Lucio Mero <\/li>\n
  • Universidad:<\/strong>\u00a0 Extremadura<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 04\/11\/2010<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Mar\u00eda Teresa Blanco Roca<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: Mar\u00eda Beltr\u00e1n dub\u00f3n <\/li>\n
        • Jos\u00e9 Prieto prieto (vocal)<\/li>\n
        • Antonio c\u00e1ndido G\u00f3mez Garc\u00eda (vocal)<\/li>\n
        • ciro P\u00e9rez giraldo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Leopoldo Lucio Mero Candida albicans y candida dubliniensis son dos pat\u00f3genos oportunistas que pueden producir infecci\u00f3n en […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[949,984,597],"tags":[9630,57502,3474,211456,6146,201237],"class_list":["post-104666","post","type-post","status-publish","format-standard","hentry","category-extremadura","category-levaduras","category-microbiologia-clinica","tag-antonio-candido-gomez-garcia","tag-ciro-perez-giraldo","tag-jose-prieto-prieto","tag-leopoldo-lucio-mero","tag-maria-beltran-dubon","tag-maria-teresa-blanco-roca"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/104666","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=104666"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/104666\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=104666"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=104666"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=104666"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}