{"id":104862,"date":"2010-12-11T00:00:00","date_gmt":"2010-12-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-anti-opoptotico-de-la-lipoxina-a4-en-macrofagos-implicaciones-en-la-resolucion-de-la-inflamacion\/"},"modified":"2010-12-11T00:00:00","modified_gmt":"2010-12-11T00:00:00","slug":"papel-anti-opoptotico-de-la-lipoxina-a4-en-macrofagos-implicaciones-en-la-resolucion-de-la-inflamacion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-anti-opoptotico-de-la-lipoxina-a4-en-macrofagos-implicaciones-en-la-resolucion-de-la-inflamacion\/","title":{"rendered":"Papel anti-opoptotico de la lipoxina a4 en macr\u00f3fagos: implicaciones en la resoluci\u00f3n de la inflamaci\u00f3n\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Patricia Prieto Chinchilla <\/strong><\/h2>\n<p>La lipoxina a4 (lxa4) es un mediador lip\u00eddico end\u00f3geno que requiere un tr\u00e1fico metab\u00f3lico transcelular para su s\u00edntesis. Las dianas de la lxa4 en los neutr\u00f3filos han sido ampliamente descritas, contribuyendo a atenuar la inflamaci\u00f3n. Sin embargo, los efectos de las lipoxinas sobre los macr\u00f3fagos son menos conocidos, en particular la acci\u00f3n de la lxa4 en la regulaci\u00f3n apopt\u00f3tica de dichas c\u00e9lulas. Nuestros datos muestran que el pre-tratamiento de macr\u00f3fagos tanto humanos como murinos con lxa4 a las concentraciones observadas en la fase de la resoluci\u00f3n de la inflamaci\u00f3n (rango nanomolar) inhibe significativamente la apoptosis inducida con estaurosporina (stau), etop\u00f3sido y gsno o por est\u00edmulos m\u00e1s patofisiol\u00f3gicos, como lps\/ifn\u00c2\u00bf. La liberaci\u00f3n de mediadores apopt\u00f3ticos mitocondriales as\u00ed como la activaci\u00f3n de las caspasas, son inhibidas en presencia de lxa4. Adem\u00e1s, el estr\u00e9s oxidativo inducido por el tratamiento con stau es atenuado y las prote\u00ednas antiapopt\u00f3ticas de la familia bcl-2 se acumulan en presencia de lxa4. El an\u00e1lisis de las dianas celulares de la lxa4 desvel\u00f3 una activaci\u00f3n temprana de las v\u00edas pi3k\/akt y erk\/nrf-2, mediadores responsables de los efectos anti-apopt\u00f3ticos observados. Estos datos sugieren que la lxa4, liberada tras el reclutamiento de los neutr\u00f3filos a los focos inflamatorios, ejerce un papel protector sobre la viabilidad de los macr\u00f3fagos que podr\u00eda contribuir a una mejor resoluci\u00f3n de la inflamaci\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel anti-opoptotico de la lipoxina a4 en macr\u00f3fagos: implicaciones en la resoluci\u00f3n de la inflamaci\u00f3n\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel anti-opoptotico de la lipoxina a4 en macr\u00f3fagos: implicaciones en la resoluci\u00f3n de la inflamaci\u00f3n\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Patricia Prieto Chinchilla <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/11\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Lisardo Bosc\u00e1 Gomar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ignacio Lizasoain hernandez <\/li>\n<li>Mar\u00eda Jos\u00e9 Mart\u00ednez d\u00edaz-guerra (vocal)<\/li>\n<li>Francisco Sobrino beneyto (vocal)<\/li>\n<li>Antonio Castrillo viguera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Patricia Prieto Chinchilla La lipoxina a4 (lxa4) es un mediador lip\u00eddico end\u00f3geno que requiere un tr\u00e1fico metab\u00f3lico [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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