{"id":104865,"date":"2010-12-11T00:00:00","date_gmt":"2010-12-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/brucelosis-cronica-y-persistencia-de-adn-de-brucella-mellitensis\/"},"modified":"2010-12-11T00:00:00","modified_gmt":"2010-12-11T00:00:00","slug":"brucelosis-cronica-y-persistencia-de-adn-de-brucella-mellitensis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/medicina-interna\/brucelosis-cronica-y-persistencia-de-adn-de-brucella-mellitensis\/","title":{"rendered":"\u00abbrucelosis cr\u00f3nica y persistencia de adn de brucella mellitensis\u00bb."},"content":{"rendered":"

Tesis doctoral de Mar\u00eda Jes\u00fas Casta\u00f1o Aroca <\/strong><\/h2>\n

Tras un episodio de brucelosis, una minor\u00eda de pacientes puede persistir con s\u00edntomas inespec\u00edficos durante m\u00e1s de un a\u00f1o. Ante la ausencia de pruebas de laboratorio objetivas que confirmen la presencia de brucella melitensis, estos pacientes sufren un retraso en el diagn\u00f3stico y tratamiento de la enfermedad. El objetivo de este estudio fue evaluar la utilidad cl\u00ednica de la detecci\u00f3n y cuantificaci\u00f3n de adn de b. Melitensis mediante un ensayo de pcr cuantitativa en tiempo real (pcrqtr) en el diagn\u00f3stico y seguimiento de estos pacientes. se incluy\u00f3 una cohorte de 38 sujetos con una historia previa de brucelosis, diagnosticada entre 3 y 33 a\u00f1os antes. Atendiendo a la evoluci\u00f3n cl\u00ednica, los sujetos se clasificaron en tres grupos: a (pacientes con enfermedad focal), b (pacientes que presentaban s\u00edntomas inespec\u00edficos como fatiga, malestar general, artralgia y\/o mialgia) y, c (sujetos asintom\u00e1ticos). Se obtuvieron un total de 694 muestras (346 de sangre, 344 de suero, una de l\u00edquido cefalorraqu\u00eddeo, una de l\u00edquido sinovial, una de m\u00e9dula \u00f3sea y una de v\u00e1lvula a\u00f3rtica). Las muestras se analizaron mediante un ensayo de pcrqtr, las pruebas serol\u00f3gicas cl\u00e1sicas (rosa de bengala, seroaglutinaci\u00f3n y coombs anti-brucella) y la prueba serol\u00f3gica no convencional brucellacapt\u00c2\u00ae. todos los pacientes con enfermedad focal o con s\u00edntomas inespec\u00edficos presentaron adn de b. Melitensis en sangre, suero u otro tipo de muestra biol\u00f3gica, frente a un 20% del grupo de sujetos asintom\u00e1ticos (prueba exacta de fisher, p< 0,001). Este resultado indica que la detecci\u00f3n de adn de b. Melitensis mediante el ensayo de pcrqtr, podr\u00eda ser de utilidad cl\u00ednica en el diagn\u00f3stico de la brucelosis cr\u00f3nica. por otra parte, durante la realizaci\u00f3n del estudio, 11 pacientes recibieron tratamiento antimicrobiano entre 45 y 540 d\u00edas. El tratamiento antimicrobiano prolongado se mostr\u00f3 como el m\u00e1s eficaz en la resoluci\u00f3n de los s\u00edntomas y la desaparici\u00f3n del adn bacteriano.\n\n\n\n \n\n\n

Datos acad\u00e9micos de la tesis doctoral \u00ab\u00abbrucelosis cr\u00f3nica y persistencia de adn de brucella mellitensis\u00bb.<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abbrucelosis cr\u00f3nica y persistencia de adn de brucella mellitensis\u00bb. <\/li>\n
  • Autor:<\/strong>\u00a0 Mar\u00eda Jes\u00fas Casta\u00f1o Aroca <\/li>\n
  • Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 12\/11\/2010<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Francisco Arnalich Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: Juan jos\u00e9 Picazo de la garza <\/li>\n
        • xavier Ariza cardenal (vocal)<\/li>\n
        • Miguel \u00e1ngel Garc\u00eda viejo (vocal)<\/li>\n
        • (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Mar\u00eda Jes\u00fas Casta\u00f1o Aroca Tras un episodio de brucelosis, una minor\u00eda de pacientes puede persistir con s\u00edntomas […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1085,139],"tags":[824,3475,211762,211763,76772],"class_list":["post-104865","post","type-post","status-publish","format-standard","hentry","category-enfermedades-infecciosas","category-medicina-interna","tag-francisco-arnalich-fernandez","tag-juan-jose-picazo-de-la-garza","tag-maria-jesus-castano-aroca","tag-miguel-angel-garcia-viejo","tag-xavier-ariza-cardenal"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/104865","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=104865"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/104865\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=104865"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=104865"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=104865"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}