{"id":104954,"date":"2018-03-11T10:28:18","date_gmt":"2018-03-11T10:28:18","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-estructural-y-funcional-de-mlsectin\/"},"modified":"2018-03-11T10:28:18","modified_gmt":"2018-03-11T10:28:18","slug":"caracterizacion-estructural-y-funcional-de-mlsectin","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/caracterizacion-estructural-y-funcional-de-mlsectin\/","title":{"rendered":"Caracterizaci\u00f3n estructural y funcional de mlsectin."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Laura Aragoneses Fenoll <\/strong><\/h2>\n<p>En el cromosoma 19p13.2 humano existe un grupo de genes que codifican lectinas de tipo c (cd23, lsectin, dc-sign, y dc-signr\/l-sign) cuya implicaci\u00f3n en la modulaci\u00f3n de la respuesta inmunitaria y reconocimiento de pat\u00f3genos ha sido claramente establ ecida. Lsectin, el miembro de este grupo de prote\u00ednas m\u00e1s recientemente identificado, participa en la captura de filovirus y virus sars, colabora con dc-signr en la uni\u00f3n de hcv, y se ha sugerido como un receptor potencial para paramixovirus.  en est a tesis se aportan evidencias de que, a diferencia de los que ocurre en el caso de dc-sign, existe un ort\u00f3logo murino para clec4g, gen que codifica lsectin en humanos, cuyo producto g\u00e9nico (mlsectin) supone un componente m\u00e1s del gran panel de mol\u00e9cul as codificadas en el cromosoma murino 8a1.1 que median captura de ant\u00edgenos y reconocimiento de pat\u00f3genos por las c\u00e9lulas del sistema inmunitario. el patr\u00f3n de expresi\u00f3n de mlsectin solapa s\u00f3lo parcialmente con el de su ort\u00f3logo humano, expres\u00e1ndose en c\u00e9lulas mieloides, como macr\u00f3fagos de bazo y peritoneales f4\/80  y c\u00e9lulas dendr\u00edticas cd11c , pero tambi\u00e9n en el componente celular no mieloide en determinados tejidos (expresi\u00f3n en lsecs en h\u00edgado).  la expresi\u00f3n basal de mlsectin es independien te de la presencia de il-4 e il-13, as\u00ed como de mol\u00e9culas implicadas en la adquisici\u00f3n de un estado de activaci\u00f3n alternativo en macr\u00f3fagos (il-4r?, Stat-6, ppar-?).  mlsectin se expresa en bajo nivel en membrana plasm\u00e1tica, lo que parece ser consecu encia de los motivos estructurales presentes en las regiones del cuello y dominio lectina, que probablemente retengan esta lectina en compartimentos intracelulares. en cuanto a su especificidad de carbohidratos, hemos demostrado que mlsectin es reten ida espec\u00edficamente por matrices de agarosa acopladas a fucosa y n-acetil-d-galactosamina. adem\u00e1s, los resultados publicados por otros autores durante el desarrollo de esta tesis sugieren que lsectin media la regulaci\u00f3n negativa de c\u00e9lulas t y presen tan a esta lectina como un candidato prometedor para el tratamiento de enfermedades hep\u00e1ticas mediadas por hiper-activaci\u00f3n de c\u00e9lulas t.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n estructural y funcional de mlsectin.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n estructural y funcional de mlsectin. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Laura Aragoneses Fenoll <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/11\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Corbi Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: cristina Casals carro <\/li>\n<li>david Sancho Madrid (vocal)<\/li>\n<li>Elena Fern\u00e1ndez ruiz (vocal)<\/li>\n<li>Miguel \u00e1ngel Vega palacios (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Laura Aragoneses Fenoll En el cromosoma 19p13.2 humano existe un grupo de genes que codifican lectinas de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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