{"id":104959,"date":"2018-03-11T10:28:18","date_gmt":"2018-03-11T10:28:18","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/pharmacogenomic-study-of-opioid-addicts-in-methadone-treatment\/"},"modified":"2018-03-11T10:28:18","modified_gmt":"2018-03-11T10:28:18","slug":"pharmacogenomic-study-of-opioid-addicts-in-methadone-treatment","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/psiquiatria\/pharmacogenomic-study-of-opioid-addicts-in-methadone-treatment\/","title":{"rendered":"Pharmacogenomic study of opioid addicts in methadone treatment"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francina Fonseca Casals <\/strong><\/h2>\n<p>Los programas de mantenimiento con metadona (pmm) han demostrado eficacia en el tratamiento del trastorno por dependencia de opi\u00e1ceos pese a la persistencia de pacientes que presentan mala respuesta al tratamiento. El estudio de los factores farmacodin\u00e1micos y farmacocin\u00e9ticos implicados en la respuesta terap\u00e9utica ofrece resultados controvertidos. El objetivo de la tesis doctoral que es presenta es estudiar los factores farmacodin\u00e1micos y farmacocin\u00e9ticos de la metadona que pueden estar implicados en la eficacia del tratamiento.  se han incluido pacientes ambulatorios diagnosticados de trastorno por dependencia de opi\u00e1ceos (seg\u00fan criterios dsm-iv) en pmm. Los pacientes han sido evaluados a nivel cl\u00ednico y se han obtenido muestras de sangre para el estudio de las concentraciones plasm\u00e1ticas de (r,s)-, (r) y (s)- metadona. Se han estudiado tambi\u00e9n las variantes al\u00e9licas de los genes que codifican para bdnf, oprm1, myocd, mglur6, mglur8, cry1, nr4a2, 1q31.2 (rs965972), 2q21.2 (rs1867898), cyp3a5, cyp2d6, cyp2b6, cyp2c9, cyp2c19 y p-glicoprote\u00edna. La muestra se ha dividido en buena y mala respuesta en funci\u00f3n del n\u00famero de controles de orina positivos para hero\u00edna en las anal\u00edticas realizadas de forma aleatoria.  se detectaron diferencias en la respuesta terap\u00e9utica seg\u00fan las variantes de los genes que codifican para bdnf, myocd y grm6. Tambi\u00e9n se ha detectado una asociaci\u00f3n entre el fenotipo del gen cyp2d6, la respuesta al tratamiento, la dosis de metadona requerida y las concentraciones plasm\u00e1ticas de \u00e9sta.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Pharmacogenomic study of opioid addicts in methadone treatment<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Pharmacogenomic study of opioid addicts in methadone treatment <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francina Fonseca Casals <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/11\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael De La Torre Fornell<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: chin b Eap <\/li>\n<li>josep eladi Ba\u00f1os diez (vocal)<\/li>\n<li>Jos\u00e9 P\u00e9rez de los cobos peris (vocal)<\/li>\n<li>Antonio Bulbena vilarrasa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francina Fonseca Casals Los programas de mantenimiento con metadona (pmm) han demostrado eficacia en el tratamiento del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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