{"id":105037,"date":"2018-03-11T10:28:23","date_gmt":"2018-03-11T10:28:23","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-regulacion-de-la-traduccion-del-virus-sindbis-implicacion-en-el-desarrollo-de-virus-oncola%c2%adticos\/"},"modified":"2018-03-11T10:28:23","modified_gmt":"2018-03-11T10:28:23","slug":"estudio-de-la-regulacion-de-la-traduccion-del-virus-sindbis-implicacion-en-el-desarrollo-de-virus-oncola%c2%adticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-regulacion-de-la-traduccion-del-virus-sindbis-implicacion-en-el-desarrollo-de-virus-oncola%c2%adticos\/","title":{"rendered":"Estudio de la regulaci\u00f3n de la traducci\u00f3n del virus sindbis. implicaci\u00f3n en el desarrollo de virus oncol\u00edticos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Rene Toribio Lopez <\/strong><\/h2>\n<p>A s\u00edntesis de prote\u00ednas o traducci\u00f3n ocupa un papel central en la expresi\u00f3n gen\u00e9tica de la c\u00e9lula ya que permite convertir (traducir) la informaci\u00f3n contenida en los tripletes (codones) del arnm en amino\u00e1cidos, dando lugar a una cadena polipept\u00eddica o prote\u00edna. La traducci\u00f3n es uno de los procesos de mayor coste energ\u00e9tico para la c\u00e9lula y su ritmo influye enormemente en la proliferaci\u00f3n y en la diferenciaci\u00f3n celular y tisular (holland et al. 2004). La s\u00edntesis de prote\u00ednas ocurre exclusivamente en los ribosomas (citos\u00f3licos o asociados a ret\u00edculo) que constituyen un complejo macromolecular con categor\u00eda de org\u00e1nulo. El ribosoma completo (80s) est\u00e1 formado por dos subunidades; la 40s compuesta por el arnr 18s y la subunidad 60s formada por los arnr 28s, 5s y 5,8s. Adem\u00e1s, cada una de las subunidades est\u00e1n formadas por decenas de prote\u00ednas distintas, algunas de las cuales se encuentran asociadas de manera estable para formar el n\u00facleo (core) estructural del ribosoma y de manera transitoria encargadas de regular la actividad del ribosoma durante las diferentes etapas de la s\u00edntesis de prote\u00ednas. La funci\u00f3n del ribosoma va m\u00e1s all\u00e1 de su papel puramente mec\u00e1nico en la fabricaci\u00f3n de prote\u00ednas, ya que asociada a esta actividad se encuentran otras como las que garantizan el correcto plegamiento y destino de las prote\u00ednas que se van sintetizando. La traducci\u00f3n se puede dividir en tres etapas b\u00e1sicas: iniciaci\u00f3n, elongaci\u00f3ny terminaci\u00f3n (groppo et al. 2009, hershey 1991, jackson et al. 2010). El ribosoma completo 80s es el \u00fanico competente en elongaci\u00f3n, mientras que la etapa de reclutamiento del arnm e iniciaci\u00f3n la lleva a cabo la subunidad 40s.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la regulaci\u00f3n de la traducci\u00f3n del virus sindbis. implicaci\u00f3n en el desarrollo de virus oncol\u00edticos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la regulaci\u00f3n de la traducci\u00f3n del virus sindbis. implicaci\u00f3n en el desarrollo de virus oncol\u00edticos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Rene Toribio Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/11\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ivan Jose Ventoso Bande<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Ortin monton <\/li>\n<li>ramon Alemany bonastre (vocal)<\/li>\n<li>cristian Smerdou picazo (vocal)<\/li>\n<li>Marta Nieto l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Rene Toribio Lopez A s\u00edntesis de prote\u00ednas o traducci\u00f3n ocupa un papel central en la expresi\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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