{"id":105065,"date":"2018-03-11T10:28:27","date_gmt":"2018-03-11T10:28:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-del-ciclo-celular-y-el-desarrollo-de-tumores-in-vivo-por-inhibidores-ink4-y-cip-kip\/"},"modified":"2018-03-11T10:28:27","modified_gmt":"2018-03-11T10:28:27","slug":"regulacion-del-ciclo-celular-y-el-desarrollo-de-tumores-in-vivo-por-inhibidores-ink4-y-cip-kip","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-del-ciclo-celular-y-el-desarrollo-de-tumores-in-vivo-por-inhibidores-ink4-y-cip-kip\/","title":{"rendered":"Regulaci\u00f3n del ciclo celular y el desarrollo de tumores in vivo por inhibidores ink4 y cip\/kip"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Victor Quereda Sanchez <\/strong><\/h2>\n<p>La desregulaci\u00f3n del ciclo celular es un fen\u00f3meno fundamental en el desarrollo del c\u00e1ncer. el conocimiento de las bases moleculares que llevan a esta desregulaci\u00f3n supone por tanto uno de los pilares b\u00e1sicos en el estudio del c\u00e1ncer. La hiperactivaci\u00f3n de las quinasas dependeientes de ciclinas (cdks) es una de las alteraciones moleculares que aparecen con m\u00e1s frecuencia en las c\u00e9lulas tumorales. Los inhibidores de cdks de las familias ink4 y cip\/kip han sido relacionados con la senescencia celular y supresi\u00f3n tumoral, aunque tampoco se puede descartar un papel oncog\u00e9nico en determinadas condiciones. Para comprender el papel de estos inhibidores y su efecto sin\u00e9rgico hemos caracterizado in vitro e in vivo el efecto producido al combinar la eliminaci\u00f3n de p21cip1 y p27kip1 en un fondo gen\u00e9tico cdk4 r24c, que hace a esta prote\u00edna insensible a la inhibici\u00f3n por las prote\u00ednas de la familia ink4. Hemos podido comprobar como la inactivaci\u00f3n conjunta de las v\u00edas de se\u00f1alizaci\u00f3n de p21cip1 e ink4 cooperan en la supresi\u00f3n de la senescencia celular in vitro y en la aparici\u00f3n de tumores in vivo, especialmente los de origen mesenquimal. Seg\u00fan vamos introduciendo mutaciones en los distintos alelos de cdk4 r24c, p21cip1 y p27kip1, la latencia en la aparici\u00f3n de tumores va disminuyendo y el origen se va restringiendo hacia los de origen endocrino, especialmente los tumores de hip\u00f3fisis. en colaboraci\u00f3n con el grupo de clara \u00e1lvarez de la universidad de santiago de compostela hemos caracterizado un tipo celular espec\u00edfico en este \u00f3rgano con caracter\u00edsticas de c\u00e9lulas madres y hemos estudiado la desregulaci\u00f3n de estas c\u00e9lulas progenitoras en los distintos modelos. Finalmente, la inactivaci\u00f3n combinada de los inhibidores ink4 (en el modelo cdk4 r24c) y de p21cip1 y p27kip1 provoca una hipoplasia generalizada probablemente debido al estr\u00e9s replicativo provocado por la p\u00e9rdida de los frenos del ciclo celular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n del ciclo celular y el desarrollo de tumores in vivo por inhibidores ink4 y cip\/kip<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n del ciclo celular y el desarrollo de tumores in vivo por inhibidores ink4 y cip\/kip <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Victor Quereda Sanchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/11\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marcos Malumbres Mart\u00ednez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  clara Alvarez villamarin <\/li>\n<li>amancio Carnero moya (vocal)<\/li>\n<li>Miguel Campanero garcia (vocal)<\/li>\n<li>sagrario Ortega jim\u00e9nez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Victor Quereda Sanchez La desregulaci\u00f3n del ciclo celular es un fen\u00f3meno fundamental en el desarrollo del c\u00e1ncer. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[14450,53260,64131,140557,119023,212070],"class_list":["post-105065","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-amancio-carnero-moya","tag-marcos-malumbres-Martinez","tag-maria-clara-alvarez-villamarin","tag-miguel-campanero-garcia","tag-sagrario-ortega-jimenez","tag-victor-quereda-sanchez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/105065","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=105065"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/105065\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=105065"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=105065"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=105065"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}