{"id":105098,"date":"2018-03-11T10:28:27","date_gmt":"2018-03-11T10:28:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-pronosticos-y-predictivos-de-respuesta-al-tratamiento-antiangiogenico-especa%c2%adfico-en-pacientes-con-carcinoma-de-rinon-avanzado\/"},"modified":"2018-03-11T10:28:27","modified_gmt":"2018-03-11T10:28:27","slug":"factores-pronosticos-y-predictivos-de-respuesta-al-tratamiento-antiangiogenico-especa%c2%adfico-en-pacientes-con-carcinoma-de-rinon-avanzado","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/factores-pronosticos-y-predictivos-de-respuesta-al-tratamiento-antiangiogenico-especa%c2%adfico-en-pacientes-con-carcinoma-de-rinon-avanzado\/","title":{"rendered":"Factores pron\u00f3sticos y predictivos de respuesta al tratamiento antiangiog\u00e9nico espec\u00edfico en pacientes con carcinoma de ri\u00f1\u00f3n avanzado."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carolina Muriel L\u00f3pez <\/strong><\/h2>\n<p>A partir del descubrimiento de las v\u00edas moleculares implicadas en el desarrollo y progresi\u00f3n del carcinoma renal avanzado (cra), se han desarrollado f\u00e1rmacos biol\u00f3gicos espec\u00edficos que han cambiado el panorama terap\u00e9utico de esta enfermedad con respecto a los resultados ofrecidos previamente por el tratamiento inmunol\u00f3gico inespec\u00edfico. En esta etapa actual, adem\u00e1s de los factores cl\u00e1sicos cl\u00ednicos y anal\u00edticos empleados en el pron\u00f3stico del cra, es preciso buscar factores nuevos con car\u00e1cter biol\u00f3gico, que ayuden a estratificar mejor a los pacientes en grupos pron\u00f3sticos y a seleccionar  aquellos que sean candidatos a las nuevas terapias dirigidas sist\u00e9micas, mejorando las respuestas y minimizando la exposici\u00f3n innecesaria a toxicidades. En base a ello, la finalidad de este trabajo ha sido confirmar cl\u00ednicamente la ventaja de los agentes biol\u00f3gicos y analizar el significado pron\u00f3stico y predictivo de respuesta de la expresi\u00f3n mediante tissue-microarrays de marcadores biol\u00f3gicos tales como el factor inducible por la hipoxia-1\u00c2\u00bf (hif-1\u00c2\u00bf), anhidrasa carb\u00f3nica ix (acix), hom\u00f3logo de la fosfatasa y tensina deleccionado en el cromosoma diez (pten) y p21 as\u00ed como de otros marcadores anal\u00edticos diferentes a los cl\u00e1sicos como la trombocitosis y neutrofilia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores pron\u00f3sticos y predictivos de respuesta al tratamiento antiangiog\u00e9nico espec\u00edfico en pacientes con carcinoma de ri\u00f1\u00f3n avanzado.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores pron\u00f3sticos y predictivos de respuesta al tratamiento antiangiog\u00e9nico espec\u00edfico en pacientes con carcinoma de ri\u00f1\u00f3n avanzado. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carolina Muriel L\u00f3pez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/11\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Emilio Esteban Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  aurora Astudillo gonzalez <\/li>\n<li>melchor Alvarez de mon soto (vocal)<\/li>\n<li>Jos\u00e9 pablo Maroto  rey (vocal)<\/li>\n<li>Jos\u00e9 Luis Gonz\u00e1lez larriba (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carolina Muriel L\u00f3pez A partir del descubrimiento de las v\u00edas moleculares implicadas en el desarrollo y progresi\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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