{"id":105112,"date":"2018-03-11T10:28:32","date_gmt":"2018-03-11T10:28:32","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mechanisms-of-fluoroquinolone-resistance-in-escherichia-coli-salmonella-typhimurium-and-yersinia-enterocolitica-influence-on-expression-of-virulence-factors\/"},"modified":"2018-03-11T10:28:32","modified_gmt":"2018-03-11T10:28:32","slug":"mechanisms-of-fluoroquinolone-resistance-in-escherichia-coli-salmonella-typhimurium-and-yersinia-enterocolitica-influence-on-expression-of-virulence-factors","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/microbiologia-clinica\/mechanisms-of-fluoroquinolone-resistance-in-escherichia-coli-salmonella-typhimurium-and-yersinia-enterocolitica-influence-on-expression-of-virulence-factors\/","title":{"rendered":"Mechanisms of fluoroquinolone resistance in escherichia coli, salmonella typhimurium and yersinia enterocolitica. influence on expression of virulence factors"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Anna F\u00e1brega Santamaria <\/strong><\/h2>\n<p>Las quinolones son una familia de antibacterianos cuyo uso ha ido en aumento durante los \u00faltimos a\u00f1os, especialmente el grupo de las fluoroquinolonas. Son \u00fatiles para tratar distintos tipos de infecciones, como por ejemplo, las infecciones del tracto urinario causadas por escherichia coli, as\u00ed como las enteritis causadas por salmonella enterica i yersinia enterocolitica. el objetivo de esta tesis es estudiar los mecanismos moleculares de adquisici\u00f3n de resistencia a las fluoroquinolonas en estos tres pat\u00f3genos mencionados. Adem\u00e1s, evaluar el efecto que dicha resistencia causa sobre la capacidad de expresar factores de virulencia tambi\u00e9n es de inter\u00e9s. el punto de inicio son cuatro cepas cl\u00ednicas, una de e. Coli, dos de s. Typhimurium y una de y. Enterocolitica. Para cada una de las cepas se ha conseguido en el laboratorio un mutante resistente a la norfloxacina, en el caso de e. Coli, o a la ciprofloxacina en el resto. El principal objetivo es analizar de manera comparativa los mecanismos de adquisici\u00f3n de resistencia a las fluoroquinolonas en cada pat\u00f3geno y observar el efecto de dicha adquisici\u00f3n sobre la expresi\u00f3n de factores de virulencia como los que codifican para el fenotipo invasivo de salmonella y yersinia como los que determinan la produccion de biofilm en salmonella. en el caso de las cepas de e. Coli el estudio se centra en la caracterizaci\u00f3n de prote\u00ednas de la envuelta bacteriana que puedan participar activamente en la adquisici\u00f3n de resistencia, as\u00ed como profundizar en su regulaci\u00f3n g\u00e9nica. en el caso de las cepas de origen ent\u00e9rico el trabajo se centra en determinar si existe alguna vinculaci\u00f3n posible entre la adquisici\u00f3n de resistencia a las fluoroquinolonas y un descenso en la capacidad invasiva, de manera que se pueda justificar porqu\u00e9 no se recuperan aislados cl\u00ednicos pat\u00f3genos que sean resistentes a esta familia de antibi\u00f3ticos, como la ciprofloxacina, pero en cambio s\u00ed que se recuperan aislados que solo son resistentes a las quinolonas como el \u00e1cido nalid\u00edxico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mechanisms of fluoroquinolone resistance in escherichia coli, salmonella typhimurium and yersinia enterocolitica. influence on expression of virulence factors<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mechanisms of fluoroquinolone resistance in escherichia coli, salmonella typhimurium and yersinia enterocolitica. influence on expression of virulence factors <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Anna F\u00e1brega Santamaria <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/11\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jordi Vila Estape<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: josep Casadesus pursals <\/li>\n<li>Jos\u00e9 ignacio Badiola s\u00e1iz (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Anna F\u00e1brega Santamaria Las quinolones son una familia de antibacterianos cuyo uso ha ido en aumento durante [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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