{"id":105219,"date":"2018-03-11T10:28:38","date_gmt":"2018-03-11T10:28:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-y-aplicaciones-de-nuevos-heterociclos-a-partir-de-iminas-quirales\/"},"modified":"2018-03-11T10:28:38","modified_gmt":"2018-03-11T10:28:38","slug":"sa%c2%adntesis-y-aplicaciones-de-nuevos-heterociclos-a-partir-de-iminas-quirales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/compuestos-heterociclicos\/sa%c2%adntesis-y-aplicaciones-de-nuevos-heterociclos-a-partir-de-iminas-quirales\/","title":{"rendered":"S\u00edntesis y aplicaciones de nuevos heterociclos a partir de iminas quirales"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Bel\u00e9n Ant\u00f3n  Mart\u00ednez <\/strong><\/h2>\n<p>En este trabajo de investigaci\u00f3n se han desarrollado nuevas metodolog\u00edas sint\u00e9ticas para la obtenci\u00f3n de pirrolinas, pirroles y pirrolidinas quirales.  en primer lugar se ha llevado a cabo la s\u00edntesis de la imina derivada del gliceraldeh\u00eddo para el estudio de la reacci\u00f3n de adici\u00f3n del ani\u00f3n del 2-propiniloxitetrahidropirano para la obtenci\u00f3n de pirrolinas quirales, intermedios muy valiosos para la s\u00edntesis de compuestos con actividad biol\u00f3gica. Adem\u00e1s dichas pirrolinas por tratamiento con ddq en dcm nos han llevado a la s\u00edntesis de un nuevo pirrol quiral, sint\u00f3n de gran utilidad en s\u00edntesis asim\u00e9trica. aprovechando la metodolog\u00eda de adici\u00f3n de derivados de li a iminas para la obtenci\u00f3n de pirrolinas y pirroles quirales, se han sintetizado distintas pirrolidinas, las cuales se pueden emplear como catalizadores org\u00e1nicos. por otra parte, se ha puesto de manifiesto la no enantioselectividad esperable de la dihidroxilaci\u00f3n de sharpless en sustratos pirrolid\u00ednicos con diferentes ligandos. La estereoqu\u00edmica de los diferentes dioles fue establecida inequ\u00edvocamente mediante s\u00edntesis de compuestos conocidos previamente.  siguiendo con la obtenci\u00f3n de pirrolidinas, se han sintetizado compuestos an\u00e1logos de la prolina a partir del producto comercial n-(t-butoxicarbonil)-l-prolina que se han utilizado como catalizadores org\u00e1nicos en reacciones que transcurren mediante intermedios tipo enamina como son las adiciones de michael de cetonas a nitroestirenos logr\u00e1ndose muy buenos rendimientos, as\u00ed como excelentes diastereo y enantioselectivadades.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis y aplicaciones de nuevos heterociclos a partir de iminas quirales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis y aplicaciones de nuevos heterociclos a partir de iminas quirales <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Bel\u00e9n Ant\u00f3n  Mart\u00ednez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/11\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>David D\u00edez Mart\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Jim\u00e9nez-barbero <\/li>\n<li>pilar Basabe barcala (vocal)<\/li>\n<li>margarita Parra \u00e1lvarez (vocal)<\/li>\n<li>Alberto Avenoza aznar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Bel\u00e9n Ant\u00f3n Mart\u00ednez En este trabajo de investigaci\u00f3n se han desarrollado nuevas metodolog\u00edas sint\u00e9ticas para la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1412,9386],"tags":[18908,120102,2804,43719,9623,65371],"class_list":["post-105219","post","type-post","status-publish","format-standard","hentry","category-compuestos-heterociclicos","category-salamanca","tag-alberto-avenoza-aznar","tag-ana-belen-anton-Martinez","tag-david-diez-martin","tag-jesus-jimenez-barbero","tag-margarita-parra-alvarez","tag-pilar-basabe-barcala"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/105219","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=105219"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/105219\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=105219"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=105219"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=105219"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}