{"id":105250,"date":"2018-03-11T10:28:43","date_gmt":"2018-03-11T10:28:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-y-caracterizacion-de-una-formulacion-topica-de-anfotericinab-con-gamma-ciclodextrina\/"},"modified":"2018-03-11T10:28:43","modified_gmt":"2018-03-11T10:28:43","slug":"desarrollo-y-caracterizacion-de-una-formulacion-topica-de-anfotericinab-con-gamma-ciclodextrina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/desarrollo-y-caracterizacion-de-una-formulacion-topica-de-anfotericinab-con-gamma-ciclodextrina\/","title":{"rendered":"Desarrollo y caracterizaci\u00f3n de una formulaci\u00f3n t\u00f3pica de anfotericinab con gamma ciclodextrina."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Helga Karina Ruiz Salda\u00f1a <\/strong><\/h2>\n<p>La presente tesis doctoral plantea el desarrollo de nuevas formulaciones t\u00f3picas de anfotericina b, considerando que este f\u00e1rmaco antif\u00fangico en la actualidad tiene el mayor espectro de acci\u00f3n y una efectividad elevada y constituye el patr\u00f3n de refer encia para la comparaci\u00f3n de nuevos f\u00e1rmacos antimic\u00f3ticos, adem\u00e1s de ser un f\u00e1rmaco indicado tambi\u00e9n en el tratamiento de leishmaniosis. El inconveniente que presenta la anfotericina b es su baja solubilidad en medio acuoso, por lo cual se plante\u00f3 m ejorarla mediante la formaci\u00f3n de complejos con las ciclodextrinas, espec\u00edficamente la ?-Ciclodextrina, un oligosac\u00e1rido c\u00edclico capaz de formar complejos de inclusi\u00f3n con numerosos f\u00e1rmacos,  mejorando sus solubilidad y sus caracter\u00edsticas terap\u00e9uti cas. Con las formulaciones t\u00f3picas desarrolladas a partir de este complejo con la ?-Ciclodextrina, que incluyen gel, crema, y colirio, se hicieron ensayos in vitro utilizando varias especies de levaduras. Estos estudios han demostrado, entre otros as pectos, la capacidad de la formulaci\u00f3n de inhibir la formaci\u00f3n de biopel\u00edculas f\u00fangicas, as\u00ed como la de penetrar en \u00e9stas cuando ya han sido formadas, lo cual es muy importante considerando el alto \u00edndice de infecciones producidas por cat\u00e9teres, pr\u00f3t esis y otros dispositivos. Con los resultados obtenidos, podemos considerar a esta nueva formulaci\u00f3n como una buena alternativa en el tratamiento y prevenci\u00f3n de micosis superficiales y mucocut\u00e1neas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo y caracterizaci\u00f3n de una formulaci\u00f3n t\u00f3pica de anfotericinab con gamma ciclodextrina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo y caracterizaci\u00f3n de una formulaci\u00f3n t\u00f3pica de anfotericinab con gamma ciclodextrina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Helga Karina Ruiz Salda\u00f1a <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/11\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Jose Torrado Duran<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: c\u00e9sar Nombela cano <\/li>\n<li>Jos\u00e9 Luis Lastres garcia (vocal)<\/li>\n<li>Jes\u00fas Molpeceres Garc\u00eda del pozo (vocal)<\/li>\n<li>Antonio Rezusta l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Helga Karina Ruiz Salda\u00f1a La presente tesis doctoral plantea el desarrollo de nuevas formulaciones t\u00f3picas de anfotericina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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