{"id":10527,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1996\/01\/01\/tetrahidrobenzofurocumarinas-benzofurocumarinas-potentes-inhibidores-del-adn\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"tetrahidrobenzofurocumarinas-benzofurocumarinas-potentes-inhibidores-del-adn","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/tetrahidrobenzofurocumarinas-benzofurocumarinas-potentes-inhibidores-del-adn\/","title":{"rendered":"Tetrahidrobenzofurocumarinas, benzofurocumarinas: potentes inhibidores del adn."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rocio Miranda Perez <\/strong><\/h2>\n<p>Se prepararon varias series de compuestos de esqueleto tetraciclico de tetrahidrobenzofurocumarina y benzofurocumarina lineares (psoralenos) y angulares (angelicinas y allopsoralenos), exentos de sustitucion o sustituidos por grupos de diversa naturaleza y longitud, y en diferentes posiciones de la estructura base, con el objetivo de estudiar su potencialidad farmacologica y contribuir al conocimiento del mecanismo de accion y al establecimiento de los requerimientos estructurales basicos de este grupo de farmacos.La sintesis se consiguio por procedimientos directos, sencillos y facilmente generalizables, obteniendo los esqueletos, los esqueletos funcionalizados (grupos metoxilo, hidroxilo, nitro o amino), y finalmente diferentes cadenas tipo eter o amida, siempre con la presencia de un grupo amino terminal.Los resultados preliminares de la actividad biologica indican que, en general, estos compuestos muestran una buena solubilidad en agua, una buena constante de asociacion al adn, una buena capacidad de inhibicion del crecimiento celular que se manifiesta tambien muy potente en ausencia de radiacion, y una ausencia de toxicidad cutanea, lo que los convierte en un tipo de compuestos con un gran perfil farmacologico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tetrahidrobenzofurocumarinas, benzofurocumarinas: potentes inhibidores del adn.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tetrahidrobenzofurocumarinas, benzofurocumarinas: potentes inhibidores del adn. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rocio Miranda Perez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eugenio Uriarte Villares<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Enrique Ravi\u00f1a Rubira <\/li>\n<li>Bernardo Celda Mu\u00f1oz (vocal)<\/li>\n<li> Gallo Mezo Miguel Angel (vocal)<\/li>\n<li>Gloria Rosell Pellis\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rocio Miranda Perez Se prepararon varias series de compuestos de esqueleto tetraciclico de tetrahidrobenzofurocumarina y benzofurocumarina lineares [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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