{"id":105313,"date":"2018-03-11T10:28:48","date_gmt":"2018-03-11T10:28:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-terapia-fotodinamica-y-sus-implicaciones-en-la-prevencion-de-queratosis-actinicas-y-carcinoma-epidermoide\/"},"modified":"2018-03-11T10:28:48","modified_gmt":"2018-03-11T10:28:48","slug":"la-terapia-fotodinamica-y-sus-implicaciones-en-la-prevencion-de-queratosis-actinicas-y-carcinoma-epidermoide","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/dermatologia\/la-terapia-fotodinamica-y-sus-implicaciones-en-la-prevencion-de-queratosis-actinicas-y-carcinoma-epidermoide\/","title":{"rendered":"La terapia fotodin\u00e1mica y sus implicaciones en la prevenci\u00f3n de queratosis act\u00ednicas y carcinoma epidermoide."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lorea Bagazgoitia S\u00e1ez De Vicu\u00f1a <\/strong><\/h2>\n<p>El presente trabajo, llevado a cabo en 22 pacientes con qas, demuestra que:  1.\tEl tratamiento con tfd tiene efectos celulares y moleculares que apoyan su efecto preventivo en qa ya que:  a)\treduce la displasia queratinoc\u00edtica basal y la elastosis solar, ambos indicadores de da\u00f1o act\u00ednico cr\u00f3nico.  b)\treduce la proliferaci\u00f3n celular de la epidermis, reflejada por una disminuci\u00f3n significativa de la expresi\u00f3n de ki-67 en todos los casos analizados.  c)\treduce la expresi\u00f3n de p53, marcador precoz de oncog\u00e9nesis en la epidermis.  2.\tUn \u00fanico tratamiento de tfd parece no ser suficiente para eliminar por completo los signos histol\u00f3gicos y moleculares de da\u00f1o act\u00ednico ya que, tras el tratamiento persisten la displasia, elastosis, positividad de p53, ciclina d1 y cox-2 en un porcentaje variable de pacientes. Esto apoya lo ya publicado en diversos estudios cl\u00ednicos que postulan una mayor eficacia de dos tratamientos de tfd frente a uno.  3.\tTras el tratamiento con tfd existe una tendencia al incremento de la expresi\u00f3n de cox-2, considerado marcador de carcinog\u00e9nesis, cuyas implicaciones deber\u00e1n ser evaluadas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La terapia fotodin\u00e1mica y sus implicaciones en la prevenci\u00f3n de queratosis act\u00ednicas y carcinoma epidermoide.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La terapia fotodin\u00e1mica y sus implicaciones en la prevenci\u00f3n de queratosis act\u00ednicas y carcinoma epidermoide. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lorea Bagazgoitia S\u00e1ez De Vicu\u00f1a <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/11\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Ja\u00e9n Olasolo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: salvador Gonz\u00e1lez rodr\u00edguez <\/li>\n<li>Mar\u00eda del pilar Gonz\u00e1lez-peramato guti\u00e9rrez (vocal)<\/li>\n<li>Francisco Sanz rodriguez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lorea Bagazgoitia S\u00e1ez De Vicu\u00f1a El presente trabajo, llevado a cabo en 22 pacientes con qas, demuestra [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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