{"id":105443,"date":"2010-03-12T00:00:00","date_gmt":"2010-03-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/anomalias-del-sistema-de-conduccion-cardiaco-asociadas-a-remodelacion-de-canales-ionicos-durante-el-desarrollo-en-un-modelo-transgenico-de-sindrome-qt-largo\/"},"modified":"2010-03-12T00:00:00","modified_gmt":"2010-03-12T00:00:00","slug":"anomalias-del-sistema-de-conduccion-cardiaco-asociadas-a-remodelacion-de-canales-ionicos-durante-el-desarrollo-en-un-modelo-transgenico-de-sindrome-qt-largo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/anomalias-del-sistema-de-conduccion-cardiaco-asociadas-a-remodelacion-de-canales-ionicos-durante-el-desarrollo-en-un-modelo-transgenico-de-sindrome-qt-largo\/","title":{"rendered":"Anomalias del sistema de conduccion cardiaco asociadas a remodelacion de canales ionicos durante el desarrollo en un modelo transgenico de sindrome qt-largo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Angel Jose De La Rosa Sanchez <\/strong><\/h2>\n<p>Esta tesis gira en torno a un modelo de rat\u00f3n transg\u00e9nico \u00c2\u00bf-mhc-kvlqt1-iso2-t7 que expresa un fenotipo de qt largo en ecg, trastorno de la conducci\u00f3n e hipertrofia cardiaca. El estudio se centra concretamente en la l\u00ednea h05 de este modelo que se expresa con alargamiento del qt y poca alteraci\u00f3n de la conducci\u00f3n a trav\u00e9s del nodo atrio-ventricular. El alargamiento del qt es secundario a un remodelado de la expresi\u00f3n de los canales de porasio kv implicados en la corriente ito. Tambi\u00e9n se observa aumento de la expresi\u00f3n de canal de sodio sen5a y sen1b que precede a la aparicion de hipertrofia. Mediante mapeo \u00f3ptico de la ctivaci\u00f3n cardiaca detectan un alargamiento del tiempo de activaci\u00f3n del coraz\u00f3n en los ratones transg\u00e9nicos en comparaci\u00f3n con los ratones salvajes (controles) que se asocia a alteraciones estructurales del tejido espec\u00edfico de la conducci\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Anomalias del sistema de conduccion cardiaco asociadas a remodelacion de canales ionicos durante el desarrollo en un modelo transgenico de sindrome qt-largo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Anomalias del sistema de conduccion cardiaco asociadas a remodelacion de canales ionicos durante el desarrollo en un modelo transgenico de sindrome qt-largo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Angel Jose De La Rosa Sanchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Ja\u00e9n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/12\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jorge  Nicol\u00e1s Dom\u00ednguez Mac\u00edas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joan Mar\u00eda Cinca cuscullola <\/li>\n<li>Jos\u00e9 Mar\u00eda P\u00e9rez pomares (vocal)<\/li>\n<li>david Sedmera (vocal)<\/li>\n<li>catalina Hernandez sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Angel Jose De La Rosa Sanchez Esta tesis gira en torno a un modelo de rat\u00f3n transg\u00e9nico [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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