{"id":105510,"date":"2010-10-12T00:00:00","date_gmt":"2010-10-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modelos-in-vitro-de-la-barrera-hemato-encefalica-implicacion-del-transporte-de-cortisol-en-la-depresion-y-su-modulacion-por-acidos-grasos\/"},"modified":"2010-10-12T00:00:00","modified_gmt":"2010-10-12T00:00:00","slug":"modelos-in-vitro-de-la-barrera-hemato-encefalica-implicacion-del-transporte-de-cortisol-en-la-depresion-y-su-modulacion-por-acidos-grasos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacodinamia\/modelos-in-vitro-de-la-barrera-hemato-encefalica-implicacion-del-transporte-de-cortisol-en-la-depresion-y-su-modulacion-por-acidos-grasos\/","title":{"rendered":"Modelos in vitro de la barrera hemato-encef\u00e1lica: implicaci\u00f3n del transporte de cortisol en la depresi\u00f3n y su modulaci\u00f3n por \u00e1cidos grasos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Del Carmen Navarro Fontestad <\/strong><\/h2>\n<p>El transporte a trav\u00e9s de la barrera hemato-encef\u00e1lica (bhe) es un factor muy importante en la acci\u00f3n farmacol\u00f3gica de michos f\u00e1rmacos y sustancias end\u00f3genas cuyo lugar de acci\u00f3n est\u00e1 situado en el cerebro. Se ha sugerido que una hiperactividad de la glicoprote\u00edna-p pueda ser de gran importancia en la resistencia del eje hpa para ser regulado por los glucocorticoides, lo cual es una de las alteraciones biol\u00f3gicas mejor descritas en ciertos tipos de depresi\u00f3n. Los \u00e1cidos grasos poli-insaturados (agpi) han demostrado cierta eficacia cl\u00ednica en pacientes con depresi\u00f3n, y la hip\u00f3tesis es que estos compuestos son capaces de reducir la actividad del eje hpa, como se ha demostrado en modelos animales de depresi\u00f3n. el objetivo de este trabajo es por una parte caracterizar el transporte de cortisol a trav\u00e9s de las l\u00edneas celulares mdck y mdck-mdr1, como modelos in vitro de la bhe, para confirmar su mecanismo de transporte como sustrato de glicoprote\u00edna-p, y por otra parte evaluar el efecto de los agpi sobre el transporte de cortisol en el modelo de bhe y explorar el mecanismo de acci\u00f3n. se realizaron estudios de transporte de cortisol en ambas direcciones, desde la c\u00e1mara apical hacia la basolateral y viceversa. Los experimentos in vitro demostraron que el transporte de cortisol es concentraci\u00f3n-dependiente y que est\u00e1 modulado por transportadores tanto de absorci\u00f3n como de secreci\u00f3n. Los resultados indican que los agpi aumentan el transporte de cortisol en los modelos de bhe, pero no por inhibici\u00f3n de la secreci\u00f3n mediada por glicoprote\u00edna-p, sino gracias a una fluidificaci\u00f3n de la membrana y alg\u00fan efecto sobre la integridad de las uniones estrechas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modelos in vitro de la barrera hemato-encef\u00e1lica: implicaci\u00f3n del transporte de cortisol en la depresi\u00f3n y su modulaci\u00f3n por \u00e1cidos grasos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modelos in vitro de la barrera hemato-encef\u00e1lica: implicaci\u00f3n del transporte de cortisol en la depresi\u00f3n y su modulaci\u00f3n por \u00e1cidos grasos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Del Carmen Navarro Fontestad <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/12\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Del Val Bermejo Sanz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: victor Jimenez torres <\/li>\n<li>Francisco j. Otero espinar (vocal)<\/li>\n<li>Marta Gonz\u00e1lez \u00e1lvarez (vocal)<\/li>\n<li>cecilia Fernandez lastra (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Del Carmen Navarro Fontestad El transporte a trav\u00e9s de la barrera hemato-encef\u00e1lica (bhe) es un factor [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9481,189],"tags":[61197,135389,212771,189794,56716,3309],"class_list":["post-105510","post","type-post","status-publish","format-standard","hentry","category-absorcion-de-los-farmacos","category-farmacodinamia","tag-cecilia-fernandez-lastra","tag-francisco-j-otero-espinar","tag-maria-del-carmen-navarro-fontestad","tag-maria-del-val-bermejo-sanz","tag-marta-gonzalez-alvarez","tag-victor-jimenez-torres"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/105510","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=105510"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/105510\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=105510"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=105510"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=105510"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}