{"id":105535,"date":"2010-10-12T00:00:00","date_gmt":"2010-10-12T00:00:00","guid":{"rendered":""},"modified":"2010-10-12T00:00:00","modified_gmt":"2010-10-12T00:00:00","slug":"analisis-de-polimorfismos-de-genes-implicados-en-la-regulacion-del-endotelio-y-la-inflamacion-en-pacientes-con-insuficiencia-carda%c2%adaca-y-su-relacion-con-el-tipo-de-disfuncion-ventricular-predomin","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/analisis-de-polimorfismos-de-genes-implicados-en-la-regulacion-del-endotelio-y-la-inflamacion-en-pacientes-con-insuficiencia-carda%c2%adaca-y-su-relacion-con-el-tipo-de-disfuncion-ventricular-predomin\/","title":{"rendered":"An\u00e1lisis de polimorfismos de genes implicados en la regulaci\u00f3n del endotelio y la inflamaci\u00f3n en pacientes con insuficiencia card\u00edaca y su relaci\u00f3n con el tipo de disfunci\u00f3n ventricular predominante"},"content":{"rendered":"

Tesis doctoral de Mar\u00eda Jose Ruiz Olgado <\/strong><\/h2>\n

: la insuficiencia cardiaca est\u00e1 determinada por factores gen\u00e9ticos y ambientales. El sistema endotelial y la respuesta inflamatoria son esenciales en el remodelado vascular en la insuficiencia cardiaca. Polimorfismos de genes que codifican la endotelina-1 (et-1), la sintasa endotelial del \u00f3xido n\u00edtrico (nos), la interleucina-6 (il-6) y la ciclooxigenasa-2 (cox2) podr\u00edan estar relacionados con el remodelado ventricular en pacientes con insuficiencia cardiaca. nuestro objetivo fue investigar la relaci\u00f3n entre los polimorfismos de los siguientes genes: lys198asn ( et-1), glu298asp (nos3), 765g>c (cox2) y -174g>c (il6) y el desarrollo de remodelado ventricular en pacientes con insuficiencia cardiaca. realizamos un estudio de casos y controles en el que se incluy\u00f3 a 190 pacientes con insuficiencia cardiaca, 105 con dilataci\u00f3n del ventr\u00edculo izquierdo y 85 con ventr\u00edculo izquierdo no dilatado. Se extrajo el adn de los pacientes mediante los protocolos habituales. El polimorfismo seleccionado del gen nos3 se analiz\u00f3 utilizando endonucleasas de restricci\u00f3n. El resto de polimorfismos se analiz\u00f3 mediante sondas taqman utilizando el termociclador aplied biosystem 7000. el alelo t del polimorfismo lys198asn de la endotelina-1 fue m\u00e1s prevalente de forma estad\u00edsticamente significativa en pacientes con dilataci\u00f3n del ventr\u00edculo izquierdo (40% vs 21,2%, p<0,000). No se encontraron diferencias en el resto de polimorfismos estudiados en relaci\u00f3n con la dilataci\u00f3n del ventr\u00edculo izquierdo en pacientes con insuficiencia cardiaca.\n\n\n\n \n\n\n

Datos acad\u00e9micos de la tesis doctoral \u00abAn\u00e1lisis de polimorfismos de genes implicados en la regulaci\u00f3n del endotelio y la inflamaci\u00f3n en pacientes con insuficiencia card\u00edaca y su relaci\u00f3n con el tipo de disfunci\u00f3n ventricular predominante<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis de polimorfismos de genes implicados en la regulaci\u00f3n del endotelio y la inflamaci\u00f3n en pacientes con insuficiencia card\u00edaca y su relaci\u00f3n con el tipo de disfunci\u00f3n ventricular predominante <\/li>\n
  • Autor:<\/strong>\u00a0 Mar\u00eda Jose Ruiz Olgado <\/li>\n
  • Universidad:<\/strong>\u00a0 Salamanca<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 10\/12\/2010<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Rogelio Gonzalez Sarmiento<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: enrique Molinero de Miguel <\/li>\n
        • Alberto San roman calvar (vocal)<\/li>\n
        • angel Sanchez rodriguez (vocal)<\/li>\n
        • Juan Jos\u00e9 Teller\u00eda orriols (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Mar\u00eda Jose Ruiz Olgado : la insuficiencia cardiaca est\u00e1 determinada por factores gen\u00e9ticos y ambientales. El sistema […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[932,9,139,9386],"tags":[144026,52094,49108,87776,212803,26315],"class_list":["post-105535","post","type-post","status-publish","format-standard","hentry","category-cardiologia","category-ciencias-medicas","category-medicina-interna","category-salamanca","tag-alberto-san-roman-calvar","tag-angel-sanchez-rodriguez","tag-enrique-molinero-de-miguel","tag-juan-jose-telleria-orriols","tag-maria-jose-ruiz-olgado","tag-rogelio-gonzalez-sarmiento"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/105535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=105535"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/105535\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=105535"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=105535"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=105535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}