{"id":105749,"date":"2018-03-11T10:29:24","date_gmt":"2018-03-11T10:29:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-de-genes-y-mecanismos-causativos-de-cancer-y-metastasis\/"},"modified":"2018-03-11T10:29:24","modified_gmt":"2018-03-11T10:29:24","slug":"identificacion-de-genes-y-mecanismos-causativos-de-cancer-y-metastasis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/genetica\/identificacion-de-genes-y-mecanismos-causativos-de-cancer-y-metastasis\/","title":{"rendered":"Identificaci\u00f3n de genes y mecanismos causativos de c\u00e1ncer y met\u00e1stasis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M\u00aa Dolores Ferr\u00e9s  Marc\u00f3 <\/strong><\/h2>\n<p>El c\u00e1ncer es una enfermedad compleja iniciada por el crecimiento sin control de una o de unas pocas c\u00e9lulas debido a la desregulaci\u00f3n de v\u00edas de desarrollo, genes del control del ciclo celular, genes del control de la muerte celular, genes de polaridad, adhesi\u00f3n, migraci\u00f3n, comunicaci\u00f3n celular, o genes de la memoria celular.  El reto es entender qu\u00e9 v\u00edas cooperan con qu\u00e9 factores en el inicio de un tumor, y qu\u00e9 mecanismos facilitan que algunos tumores puedan invadir y colonizar \u00f3rganos distantes (met\u00e1stasis).  La mayor\u00eda de la mortalidad asociada a los pacientes con c\u00e1ncer est\u00e1 causada por las met\u00e1stasis.  Entender c\u00f3mo se inician las met\u00e1stasis in vivo es de vital importancia para el desarrollo de nuevas terapias en el tratamiento del c\u00e1ncer y la met\u00e1stasis.  En este trabajo de tesis doctoral, utilizando una b\u00fasqueda gen\u00e9tica de alto rendimiento en el ojo de drosophila melanogaster, se han investigado mecanismos gen\u00e9ticos y moleculares por los que la desregulaci\u00f3n de la v\u00eda de desarrollo, la de notch en cooperaci\u00f3n con otros genes, transforma una c\u00e9lula epitelial sana en tumoral con capacidad para invadir, diseminarse a sitios distantes y colonizar nuevos \u00f3rganos.  Las b\u00fasquedas gen\u00e9ticas descritas en este trabajo de tesis doctoral han permitido la identificaci\u00f3n de genes que median la funci\u00f3n de notch en crecimiento del ojo y han ayudado a determinar c\u00f3mo la actividad localizada de notch estimula crecimiento a largo rango, dentro de tejidos en desarrollo.  Al mismo tiempo, est\u00e1s b\u00fasquedas gen\u00e9ticas han permitido identificar factores decisivos en el mecanismo oncog\u00e9nico de notch, particularmente en crecimiento tumoral y met\u00e1stasis.  Estos resultados y el trabajo futuro con otras genes identificados en esta b\u00fasqueda gen\u00e9tica puede ayudar a abrir nuevos caminos de investigaci\u00f3n y al dise\u00f1o de mejores estrategias de detecci\u00f3n precoz de c\u00e1nceres asociados a la desregulaci\u00f3n de la v\u00eda de notch y a cambios epigen\u00e9ticos<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Identificaci\u00f3n de genes y mecanismos causativos de c\u00e1ncer y met\u00e1stasis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Identificaci\u00f3n de genes y mecanismos causativos de c\u00e1ncer y met\u00e1stasis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M\u00aa Dolores Ferr\u00e9s  Marc\u00f3 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/12\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Dom\u00ednguez Castellano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jordi Casanova roca <\/li>\n<li>Jorge Bol\u00edvar p\u00e9rez (vocal)<\/li>\n<li>isabel Rodriguez  enriquez (vocal)<\/li>\n<li>Luis Fernando Casares fern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M\u00aa Dolores Ferr\u00e9s Marc\u00f3 El c\u00e1ncer es una enfermedad compleja iniciada por el crecimiento sin control de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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