{"id":105895,"date":"2018-03-11T10:29:38","date_gmt":"2018-03-11T10:29:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/role-of-mouse-flower-during-carcinogenesis-and-normal-mouse-development\/"},"modified":"2018-03-11T10:29:38","modified_gmt":"2018-03-11T10:29:38","slug":"role-of-mouse-flower-during-carcinogenesis-and-normal-mouse-development","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/role-of-mouse-flower-during-carcinogenesis-and-normal-mouse-development\/","title":{"rendered":"Role of mouse flower during carcinogenesis and normal mouse development."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Evgeniya Stoycheva Petrova <\/strong><\/h2>\n<p>Cell competition is a process through which unfit cells (losers) are replaced from  a tissue by neighboring optimal cells (winners). Drosophila flower protein forms a code that serves to distinguish winners from losers and, thus, mediates the initial steps of cell competition. Flower is conserved from fungi to humans. Mouse flower  encodes four protein isoforms. These mfwe proteins are membrane proteins whose exact function in the mouse is still unknown. To study mfwe function in mammals and its role during carcinogenesis, we generated a conditional and constitutive  fwe  knock-out mouse model. Fwe-deficient mice display a normal phenotype. However, deficiency of mfwe reduces the number of papillomas formed as a result of dmba\/tpa carcinogenesis protocol, but does not influence tumorigenesis in other contexts of cancer such 3-mca and aom\/dss chemical carcinogenesis or emu-myc, apcmin\/+ and p53-\/- genetic mouse models of cancer.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Role of mouse flower during carcinogenesis and normal mouse development.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Role of mouse flower during carcinogenesis and normal mouse development. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Evgeniya Stoycheva Petrova <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Moreno Lampaya<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: amparo Cano garcia <\/li>\n<li>lLuis Montoliu jose (vocal)<\/li>\n<li>Andr\u00e9s Hidalgo alonso (vocal)<\/li>\n<li>ignacio Moreno de albor\u00e1n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Evgeniya Stoycheva Petrova Cell competition is a process through which unfit cells (losers) are replaced from a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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