{"id":105968,"date":"2018-03-11T10:29:43","date_gmt":"2018-03-11T10:29:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/molecular-genetics-of-gonad-development-and-sex-determination-in-zebrafish-gena%c2%a8tica-molecular-del-desenvolupament-de-les-ga%c2%b2nades-i-de-la-determinacio-del-sexe-en-peix-zebra\/"},"modified":"2018-03-11T10:29:43","modified_gmt":"2018-03-11T10:29:43","slug":"molecular-genetics-of-gonad-development-and-sex-determination-in-zebrafish-gena%c2%a8tica-molecular-del-desenvolupament-de-les-ga%c2%b2nades-i-de-la-determinacio-del-sexe-en-peix-zebra","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/molecular-genetics-of-gonad-development-and-sex-determination-in-zebrafish-gena%c2%a8tica-molecular-del-desenvolupament-de-les-ga%c2%b2nades-i-de-la-determinacio-del-sexe-en-peix-zebra\/","title":{"rendered":"Molecular genetics of gonad development and sex determination in zebrafish (gen\u00e9tica molecular del desenvolupament de les g\u00f3nades i de la determinaci\u00f3 del sexe en peix zebra)."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Adriana Rodr\u00edguez Mar\u00ed <\/strong><\/h2>\n<p>El pez cebra se ha convertido en las \u00faltimas d\u00e9cadas en uno de los organismos modelos m\u00e1s utilizados en biolog\u00eda del desarrollo y en investigaci\u00f3n biom\u00e9dica.  A pesar de esto, los mecanismos que determinan el sexo en pez cebra a\u00fan permanecen desconocidos.  esta tesis doctoral se centra en el estudio de los mecanismos gen\u00e9ticos del desarrollo de las g\u00f3nadas y de la determinaci\u00f3n del sexo en pez cebra.  en este estudio se caracterizan genes involucrados en el desarrollo temprano de las g\u00f3nadas en pez cebra, incluyendo el gen de la hormona anti-m\u00ed\u00bclleriana (amh), gen que se cre\u00eda exclusivo de mam\u00edferos. Este estudio revela como los genes amh y cyp19a1a son unos buenos marcadores del destino masculino o femenino de las g\u00f3nadas bipotenciales, respectivamente. Tambi\u00e9n se demuestra la presencia y conservaci\u00f3n en pez cebra de varios genes implicados en el desarrollo de las g\u00f3nadas en mam\u00edferos. mediante el estudio de la diferenciaci\u00f3n de las c\u00e9lulas germinales en pez cebra que tienen genes mutados de la v\u00eda de fanconi\/brca involucrada en la reparaci\u00f3n del dna, y padecen reversi\u00f3n de sexo, este estudio revela el papel esencial de la supervivencia de los oocitos mei\u00f3ticos para determinar el destino femenino de las g\u00f3nadas y la diferenciaci\u00f3n de las hembras. De forma destacable, este estudio demuestra que la apoptosis dependiente de tp53 de las c\u00e9lulas germinales durante el per\u00edodo cr\u00edtico para la determinaci\u00f3n del destino sexual de las g\u00f3nadas de pez cebra juega un papel esencial en la determinaci\u00f3n del sexo en estos mutantes, y muestra que el fenotipo de reversi\u00f3n de sexo se puede rescatar introduciendo una mutaci\u00f3n en el gen tp53 (p53). el conjunto de resultados obtenidos durante esta tesis doctoral llevan a proponer un modelo para la determinaci\u00f3n del sexo del pez cebra en el que la apoptosis dependiente de tp53 de las c\u00e9lulas germinales juega un papel central e incorpora se\u00f1ales tanto gen\u00e9ticas como ambientales y es el balance final de la cantidad de oocitos que sobreviven lo que determina que la g\u00f3nada bipotencial entre en la v\u00eda de diferenciaci\u00f3n masculina o femenina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Molecular genetics of gonad development and sex determination in zebrafish (gen\u00e9tica molecular del desenvolupament de les g\u00f3nades i de la determinaci\u00f3 del sexe en peix zebra).<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Molecular genetics of gonad development and sex determination in zebrafish (gen\u00e9tica molecular del desenvolupament de les g\u00f3nades i de la determinaci\u00f3 del sexe en peix zebra). <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Adriana Rodr\u00edguez Mar\u00ed <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>John Postlethwait<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: lLuisa Vilageliu arqu\u00e9s <\/li>\n<li>angel Raya chamorro (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Adriana Rodr\u00edguez Mar\u00ed El pez cebra se ha convertido en las \u00faltimas d\u00e9cadas en uno de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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