{"id":105988,"date":"2018-03-11T10:29:43","date_gmt":"2018-03-11T10:29:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-en-el-metabolismo-de-la-glucosa-en-estado-de-resistencia-a-insulina-y-diabetes-tipo-2-accion-normalizadora-del-glp-1-y-de-la-exendina-4\/"},"modified":"2018-03-11T10:29:43","modified_gmt":"2018-03-11T10:29:43","slug":"alteraciones-en-el-metabolismo-de-la-glucosa-en-estado-de-resistencia-a-insulina-y-diabetes-tipo-2-accion-normalizadora-del-glp-1-y-de-la-exendina-4","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-en-el-metabolismo-de-la-glucosa-en-estado-de-resistencia-a-insulina-y-diabetes-tipo-2-accion-normalizadora-del-glp-1-y-de-la-exendina-4\/","title":{"rendered":"Alteraciones en el metabolismo de la glucosa en estado de resistencia a insulina y diabetes tipo 2: acci\u00f3n normalizadora del glp-1 y de la exendina-4"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Paola Moreno Perez <\/strong><\/h2>\n<p>La exendina-4 (ex-4) es un p\u00e9ptido de origen natural no mam\u00edfero, parcialmente hom\u00f3logo al glp-1 (glucagon like peptide-1) \u00c2\u00bfincretina insulinotr\u00f3pica dependiente de glucosa y antidiab\u00e9tica independiente de insulina\u00c2\u00bf. El glp-1 y la ex-4 comparten no s\u00f3lo su efecto antidiab\u00e9tico sino tambi\u00e9n varias de sus acciones sobre el metabolismo de la glucosa, l\u00edpidos y \u00f3seo, en tejidos extrapancre\u00e1ticos que, en el caso del glp-1, son ejercidas a trav\u00e9s de receptores espec\u00edficos, distintos, en estructura y\/o funci\u00f3n, a su receptor pancre\u00e1tico. en este trabajo se ha pretendido conocer las caracter\u00edsticas de la acci\u00f3n prolongada de la ex-4, respecto a las del glp-1, sobre par\u00e1metros relacionados con el metabolismo de la glucosa del h\u00edgado, m\u00fasculo y tejido adiposo, en estados de resistencia a insulina y diabetes tipo 2. en concreto, hemos estudiado en la rata normal, y en un modelo experimental de resistencia a insulina y otro de diabetes tipo 2, el efecto del tratamiento continuado con ex-4 y glp-1, sobre\u00c2\u00bf expresi\u00f3n del glucotransportador glut-2 y otros par\u00e1metros relacionados con el metabolismo hep\u00e1tico de la glucosa, y tambi\u00e9n la actividad de distintos enzimas participantes en sus mecanismos de acci\u00f3n celular. expresi\u00f3n del glucotransportador glut-4 y otros par\u00e1metros relacionados con el metabolismo de la glucosa del m\u00fasculo esquel\u00e9tico, y tambi\u00e9n la actividad de distintos enzimas participantes en sus mecanismos de acci\u00f3n celular. expresi\u00f3n del glucotransportador glut-4 y otros par\u00e1metros relacionados con el metabolismo de la glucosa del tejido adiposo, y tambi\u00e9n la actividad de distintos enzimas participantes en sus mecanismos de acci\u00f3n celular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones en el metabolismo de la glucosa en estado de resistencia a insulina y diabetes tipo 2: acci\u00f3n normalizadora del glp-1 y de la exendina-4<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones en el metabolismo de la glucosa en estado de resistencia a insulina y diabetes tipo 2: acci\u00f3n normalizadora del glp-1 y de la exendina-4 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Paola Moreno Perez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/2010<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>pe\u00f1acarrillo Molina Villanueva<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Bl\u00e1zquez fern\u00e1ndez <\/li>\n<li>bernardo Nuche berenguer (vocal)<\/li>\n<li>david Vicent lopez (vocal)<\/li>\n<li>rosa Mar\u00eda Arahuetes portero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Paola Moreno Perez La exendina-4 (ex-4) es un p\u00e9ptido de origen natural no mam\u00edfero, parcialmente hom\u00f3logo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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