{"id":106226,"date":"2011-10-01T00:00:00","date_gmt":"2011-10-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/synthesis-of-fatty-acid-derivatives-of-catechol-compounds-that-exhibit-negative-modulation-of-food-intake-and-antioxidant-properties\/"},"modified":"2011-10-01T00:00:00","modified_gmt":"2011-10-01T00:00:00","slug":"synthesis-of-fatty-acid-derivatives-of-catechol-compounds-that-exhibit-negative-modulation-of-food-intake-and-antioxidant-properties","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-organica\/synthesis-of-fatty-acid-derivatives-of-catechol-compounds-that-exhibit-negative-modulation-of-food-intake-and-antioxidant-properties\/","title":{"rendered":"Synthesis of fatty acid derivatives of catechol compounds that exhibit negative modulation of food intake and antioxidant properties"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Bruno Almeida Cotrim <\/strong><\/h2>\n<p>La obesidad es un problema cuyas manifestaciones tienen consecuencias en casi todos los campos de la medicina y actualmente existe una escasez de terapias farmacol\u00f3gicas para su tratamiento de uso continuo. Se sabe que algunos compuestos lip\u00eddicos como los endocanabinoides y ligandos del ppar-alfa participan de manera importante en la modulaci\u00f3n del apetito y en el metabolismo. Tres series de compuestos derivados de \u00e1cidos grasos con compuestos catec\u00f3licos fueron sintetizadas y sus actividades biol\u00f3gicas fueron evaluadas. Algunos de los compuestos present\u00f3 inhibici\u00f3n de la oxidaci\u00f3n de la ldl y\/o modulaci\u00f3n de la ingesta en modelo animal y sus mecanismos de acci\u00f3n fueron tambi\u00e9n evaluados. La actividad de los compuestos pasa por interacciones con el receptor cb1 y el ppar-alfa pero estas interacciones no explican la actividad de todos los compuestos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Synthesis of fatty acid derivatives of catechol compounds that exhibit negative modulation of food intake and antioxidant properties<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Synthesis of fatty acid derivatives of catechol compounds that exhibit negative modulation of food intake and antioxidant properties <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Bruno Almeida Cotrim <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/01\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael De La Torre Fornell<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: david Andreu mart\u00ednez <\/li>\n<li>Emilio Fernandez espejo (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bruno Almeida Cotrim La obesidad es un problema cuyas manifestaciones tienen consecuencias en casi todos los campos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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