{"id":106242,"date":"2011-11-01T00:00:00","date_gmt":"2011-11-01T00:00:00","guid":{"rendered":""},"modified":"2011-11-01T00:00:00","modified_gmt":"2011-11-01T00:00:00","slug":"nuevas-alternativas-terapeuticas-frente-a-acinetobacter-baumannii-estudios-pre-cla%c2%adnicos-de-peptidos-ha%c2%adbridos-de-cecropina-a-melitina-una-quinolona-de-nueva-generacion-ub-8902-y-acido-c","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/medicina-interna\/nuevas-alternativas-terapeuticas-frente-a-acinetobacter-baumannii-estudios-pre-cla%c2%adnicos-de-peptidos-ha%c2%adbridos-de-cecropina-a-melitina-una-quinolona-de-nueva-generacion-ub-8902-y-acido-c\/","title":{"rendered":"Nuevas alternativas terap\u00e9uticas frente a acinetobacter baumannii. estudios pre-cl\u00ednicos de p\u00e9ptidos h\u00edbridos de cecropina a-melitina, una quinolona de nueva generaci\u00f3n (ub-8902) y \u00e1cido clavul\u00e1nico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael L\u00f3pez Rojas <\/strong><\/h2>\n<p>Acinetobacter baumannii se ha convertido en un paradigma de microorganismo nosocomial emergente, debido a la importancia e implicaci\u00f3n en situaciones de endemia y brotes nosocomiales de infecci\u00f3n. Teniendo en cuenta la frecuencia cada vez m\u00e1s alta de infecciones por cepas multirresistentes, son necesarios nuevos estudios experimentales, in vitro e in vivo, que eval\u00faen nuevas alternativas terap\u00e9uticas para la infecci\u00f3n por a. Baumannii. el objetivo general de esta tesis doctoral es evaluar la actividad de nuevas mol\u00e9culas antibi\u00f3ticas in vitro y en modelos murinos de infecciones producidas por cepas cl\u00ednicas de a. Baumannii con diferentes patrones de sensibilidad. para ello, hemos desarrollado tres objetivos espec\u00edficos, uno para cada mol\u00e9cula: 1. Estudiar la eficacia de nuevas mol\u00e9culas h\u00edbridas de cecropina a-melitina [ca(1-8)m(1-18), octanoil-ca(1-7)m(2-9), ca(1-7)m(2-9) y ca(1-7)m(5-9)] en un modelo murino de infecci\u00f3n sist\u00e9mica utilizando cepas de a. Baumannii panresistente, incluyendo resistencia a colistina, a trav\u00e9s de un modelo no discriminativo como el paso inicial necesario en la valoraci\u00f3n de nuevas mol\u00e9culas antibi\u00f3ticas. Adicionalmente, se comparar\u00e1 la actividad in vivo con la observada in vitro y se evaluar\u00e1 la respuesta inflamatoria tras el tratamiento con dichos p\u00e9ptidos. 2. Evaluar la actividad de un nuevo derivado del ciprofloxacino (ub-8902) in vitro y su eficacia in vivo, tanto en un modelo experimental no discriminativo de sepsis peritoneal como en un modelo de neumon\u00eda murina producidos por a. Baumannii resistente a ciprofloxacino. 3. Determinar la actividad in vitro y la eficacia in vivo del inhibidor de betalactamasas \u00e1cido clavul\u00e1nico, en un modelo experimental de neumon\u00eda murina causado por cepas cl\u00ednicas de a. Baumannii.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevas alternativas terap\u00e9uticas frente a acinetobacter baumannii. estudios pre-cl\u00ednicos de p\u00e9ptidos h\u00edbridos de cecropina a-melitina, una quinolona de nueva generaci\u00f3n (ub-8902) y \u00e1cido clavul\u00e1nico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevas alternativas terap\u00e9uticas frente a acinetobacter baumannii. estudios pre-cl\u00ednicos de p\u00e9ptidos h\u00edbridos de cecropina a-melitina, una quinolona de nueva generaci\u00f3n (ub-8902) y \u00e1cido clavul\u00e1nico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael L\u00f3pez Rojas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/01\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jer\u00f3nimo Pachon D\u00edaz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: francesc Gudiol munt\u00e9 <\/li>\n<li>Luis Rivas l\u00f3pez (vocal)<\/li>\n<li>jordi Vila estape (vocal)<\/li>\n<li>Miguel \u00e1ngel Muniain ezcurra (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael L\u00f3pez Rojas Acinetobacter baumannii se ha convertido en un paradigma de microorganismo nosocomial emergente, debido a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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