{"id":106412,"date":"2018-03-11T10:30:19","date_gmt":"2018-03-11T10:30:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-funcional-y-cla%c2%adnica-del-epcr-como-gen-prometastasico-en-el-adenocarcinoma-de-pulmon\/"},"modified":"2018-03-11T10:30:19","modified_gmt":"2018-03-11T10:30:19","slug":"caracterizacion-funcional-y-cla%c2%adnica-del-epcr-como-gen-prometastasico-en-el-adenocarcinoma-de-pulmon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/caracterizacion-funcional-y-cla%c2%adnica-del-epcr-como-gen-prometastasico-en-el-adenocarcinoma-de-pulmon\/","title":{"rendered":"Caracterizaci\u00f3n funcional y cl\u00ednica del epcr como gen prometast\u00e1sico en el adenocarcinoma de pulm\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Iker Ant\u00f3n Ib\u00e1\u00f1ez <\/strong><\/h2>\n<p>The epcr receptor and its ligand apc have been implicated in the anticoagulant activity of endothelial cells but their role in human cancer remains largely unknown.  The aim of this study was to elucidate the function of epcr in lung adenocarcinoma. abrogation of epcr expression in lung cancer cell lines, by using two lentiviral knock down constructs dramatically reduced prometastatic activity to the bone compartment. Similarly, blocking antibodies preventing epcr-apc interaction, showed similar antimetastatic activity. These results were associated with impaired bone homing activity. As expected, epcr overexpression in lung cancer cells showed an increased metastatic activity.  Moreover, immunohistochemical analysis in a large cohort of lung cancer patients revealed a marked association between high epcr levels and poor survival or relapse in patients with stage i lung adenocarcinoma. In these patients epcr was an independent pronostic factor. Thus our results suggest that patients with stage i adenocarcinoma and high epcr may benefit from adjuvant therapy. Future studies will dissect the molecular mechanisms triggered by epcr-apc in promoting lung adenocarcinoma dissemination.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n funcional y cl\u00ednica del epcr como gen prometast\u00e1sico en el adenocarcinoma de pulm\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n funcional y cl\u00ednica del epcr como gen prometast\u00e1sico en el adenocarcinoma de pulm\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Iker Ant\u00f3n Ib\u00e1\u00f1ez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/01\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Lecanda Cordero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Javierde las Rivas sanz <\/li>\n<li>Jos\u00e9 m. L\u00f3pez-picazo gonz\u00e1lez (vocal)<\/li>\n<li>roger Gomis cabre (vocal)<\/li>\n<li>Francisco Espa\u00f1a furi\u00f3 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Iker Ant\u00f3n Ib\u00e1\u00f1ez The epcr receptor and its ligand apc have been implicated in the anticoagulant activity [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,17749],"tags":[18098,9430,214173,3402,80772,56834],"class_list":["post-106412","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-navarra","tag-fernando-lecanda-cordero","tag-francisco-espana-furio","tag-iker-anton-ibanez","tag-javierde-las-rivas-sanz","tag-jose-m-lopez-picazo-gonzalez","tag-roger-gomis-cabre"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/106412","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=106412"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/106412\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=106412"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=106412"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=106412"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}