{"id":106718,"date":"2011-09-02T00:00:00","date_gmt":"2011-09-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/neuroproteccion-de-las-celulas-ganglionares-de-la-retina-el-papel-de-los-cannabinoides-y-la-brimonidina\/"},"modified":"2011-09-02T00:00:00","modified_gmt":"2011-09-02T00:00:00","slug":"neuroproteccion-de-las-celulas-ganglionares-de-la-retina-el-papel-de-los-cannabinoides-y-la-brimonidina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/analisis-de-farmacos\/neuroproteccion-de-las-celulas-ganglionares-de-la-retina-el-papel-de-los-cannabinoides-y-la-brimonidina\/","title":{"rendered":"Neuroprotecci\u00f3n de las c\u00e9lulas ganglionares de la retina: el papel de los cannabinoides y la brimonidina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sergio Pinar Sueiro <\/strong><\/h2>\n<p>A trav\u00e9s de la presente tesis hemos tratado demostrar el efecto neuroprotector sobre las c\u00e9lulas ganglionares de la retina de la brimonidina (\u00c2\u00bf-2 agonista empleado habitualmente en la cl\u00ednica) y el agonista sint\u00e9tico de los receptores cb1\/cb2 de cannabinoides win 55212-2. Para ello empleamos un modelo experimental de cauterizaci\u00f3n de venas epiesclerales y un modelo de isquemia aguda retiniana por hipertensi\u00f3n inducida por inyecci\u00f3n de suero fisiol\u00f3gico en c\u00e1mara anterior. Asimismo, caracterizamos la expresi\u00f3n de los receptores cb1 mediante inmunohistoqu\u00edmica en los tejidos oculares de distintos modelos animales y humanos. como resultado de la experimentaci\u00f3n obtuvimos los siguientes resultados que sintetizamos a modo de conclusiones:  la brimonidina preserva m\u00e1s del 90% de las c\u00e9lulas ganglionares en el modelo de glaucoma experimental mediante cauterizaci\u00f3n de venas epiesclerales, preservando asimismo el incremento en el tama\u00f1o medio de los somas asociados a la neurodegeneraci\u00f3n secundaria. el receptor cb1 se expresa abundantemente en los segmentos anterior y posterior de las copas \u00f3pticas analizadas, siendo esta expresi\u00f3n menor en la malla trabecular de pacientes glaucomatosos frente a los controles. tanto el agonista win 55212-2 aplicado de forma t\u00f3pica, como la brimonidina t\u00f3pica e intraperitoneal ejercen un efecto neuroprotector similar sobre las c\u00e9lulas ganglionares de la retina en el modelo de isquemia aguda previamente descrito. esta protecci\u00f3n sobre las c\u00e9lulas ganglionares de la retina conseguido tras el empleo de este potente agonista de los receptores de cannabinoides es mediado por la activaci\u00f3n de los receptores cb1, al verse dicho efecto abolido con el empleo de un antagonista cb1 selectivo (am 251).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Neuroprotecci\u00f3n de las c\u00e9lulas ganglionares de la retina: el papel de los cannabinoides y la brimonidina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Neuroprotecci\u00f3n de las c\u00e9lulas ganglionares de la retina: el papel de los cannabinoides y la brimonidina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sergio Pinar Sueiro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/02\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Elena Vecino Cordero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Antonio Duran de la colina <\/li>\n<li>sansar Sharma (vocal)<\/li>\n<li>Juli\u00e1n Garcia feijoo (vocal)<\/li>\n<li>Javier Mendicute del barrio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sergio Pinar Sueiro A trav\u00e9s de la presente tesis hemos tratado demostrar el efecto neuroprotector sobre las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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