{"id":106830,"date":"2018-03-11T10:30:53","date_gmt":"2018-03-11T10:30:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-variabilidad-genetica-poblacional-del-virus-herpes-simplex-tipo-1\/"},"modified":"2018-03-11T10:30:53","modified_gmt":"2018-03-11T10:30:53","slug":"estudio-de-la-variabilidad-genetica-poblacional-del-virus-herpes-simplex-tipo-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/estudios-de-comunidades\/estudio-de-la-variabilidad-genetica-poblacional-del-virus-herpes-simplex-tipo-1\/","title":{"rendered":"Estudio de la variabilidad gen\u00e9tica poblacional del virus herpes simplex tipo 1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Nacari Jaramillo Doniush <\/strong><\/h2>\n<p>La variabilidad gen\u00e9tica del virus herpes simplex tipo 1 se ha estudiado mediante la aplicaci\u00f3n de un cuello de botella gen\u00e9tico consistente en la obtenci\u00f3n de clones v\u00edricos a trav\u00e9s de diez pases sucesivos en placa de 23 clones procedentes de una poblaci\u00f3n representada por la cepa de referencia f. Tras la realizaci\u00f3n de los pases sucesivos pudimos observar que dos clones, de un total de veintitr\u00e9s, no fueron capaces de alcanzar el \u00faltimo pase en placa en c\u00e9lulas 143tk-. Estos clones al ser inoculados en condiciones iguales en una l\u00ednea celular diferente (c\u00e9lulas vero) demuestran un notable incremento en su capacidad de producir infecci\u00f3n. En el presente estudio investigamos los posibles cambios en la secuencia de varios genes comparando los \u00c2\u00bfclones parentales\u00c2\u00bf o clones 1, con los \u00c2\u00bfclones transferidos\u00c2\u00bf o clones 10, as\u00ed como el estudio de las posibles modificaciones en la neurovirulencia de los clones transferidos en un modelo animal en rat\u00f3n. No se encontr\u00f3 ning\u00fan cambio en las secuencias de la regi\u00f3n exo iii de la dna polimerasa entre ambas poblaciones. Con respecto a los genes de la glicoprote\u00edna gd y la timidina kinasa, se detectaron cambios en las secuencias en clones virales, pertenecientes a los clones transferidos, con respecto a los clones parentales. Asimismo, los clones transferidos de las series que no mantuvieron su viabilidad hasta el d\u00e9cimo pase mostraron una neurovirulencia disminuida con respecto a los clones finales de otras series y con respecto a la poblaci\u00f3n original.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la variabilidad gen\u00e9tica poblacional del virus herpes simplex tipo 1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la variabilidad gen\u00e9tica poblacional del virus herpes simplex tipo 1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Nacari Jaramillo Doniush <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/02\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Enrique Tabares Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: esteban Domingo solans <\/li>\n<li>Jos\u00e9 Antonio L\u00f3pez guerrero (vocal)<\/li>\n<li>Luis Menendez arias (vocal)<\/li>\n<li>ricardo Fern\u00e1ndez roblas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nacari Jaramillo Doniush La variabilidad gen\u00e9tica del virus herpes simplex tipo 1 se ha estudiado mediante la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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