{"id":106853,"date":"2018-03-11T10:30:58","date_gmt":"2018-03-11T10:30:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-genetico-de-la-fosfatasa-cdc14b-en-mama%c2%adferos\/"},"modified":"2018-03-11T10:30:58","modified_gmt":"2018-03-11T10:30:58","slug":"analisis-genetico-de-la-fosfatasa-cdc14b-en-mama%c2%adferos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-genetico-de-la-fosfatasa-cdc14b-en-mama%c2%adferos\/","title":{"rendered":"An\u00e1lisis gen\u00e9tico de la fosfatasa cdc14b en mam\u00edferos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Guillamot  Ruano <\/strong><\/h2>\n<p>En levaduras, cdc14 es la fosfatasa que regula la desfosforilaci\u00f3n de los sustratos de las  quinasas dependientes de ciclinas (cdks) promoviendo la salida de mitosis. A pesar de la elevada  homolog\u00eda estructural de sus ort\u00f3logos, cdc14a y cdc14b, las funciones de estas fosfatasas en  mam\u00edferos son desconocidas. La generaci\u00f3n de un modelo de rat\u00f3n condicionalmente deficiente en  cdc14b nos ha permitido determinar la dispensabilidad de dicha fosfatasa en la divisi\u00f3n celular. Sin  embargo, los fibroblastos deficientes en cdc14b presentan una transici\u00f3n en g1\/s prematura. Si  bien, la eliminaci\u00f3n de este gen no genera ninguna anomal\u00eda  en el desarrollo de los ratones, la  ausencia de cdc14b induce una mayor susceptibilidad al desarrollo tumorog\u00e9nico in vivo. Adem\u00e1s,  estos ratones presentan oligoastenoteraozoospermia. Este hecho nos ha permitido identificar dos  nuevas funciones de esta  fosfatasa en la formaci\u00f3n de los espermatozoides. En primer lugar,  cdc14b es esencial en el punto de control del paquiteno y en segundo lugar, esta fosfatasa regula la  maduraci\u00f3n de las esperm\u00e1tidas al modular el acoplamiento cabeza-cola de los espermatozoides  maduros.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis gen\u00e9tico de la fosfatasa cdc14b en mam\u00edferos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis gen\u00e9tico de la fosfatasa cdc14b en mam\u00edferos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Guillamot  Ruano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/02\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marcos Malumbres Mart\u00ednez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: \u00f3scar Fern\u00e1ndez-capetillo ruiz <\/li>\n<li>Alberto Martin pendas (vocal)<\/li>\n<li>Mar\u00eda Sacrist\u00e1n mart\u00edn (vocal)<\/li>\n<li>Luis Arag\u00f3n alcaide (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Guillamot Ruano En levaduras, cdc14 es la fosfatasa que regula la desfosforilaci\u00f3n de los sustratos de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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