{"id":106915,"date":"2018-03-11T10:31:05","date_gmt":"2018-03-11T10:31:05","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-receptor-endovanilloide-trpv-1-sobre-la-inflamacion-y-carcinogenesis-intestinal\/"},"modified":"2018-03-11T10:31:05","modified_gmt":"2018-03-11T10:31:05","slug":"papel-del-receptor-endovanilloide-trpv-1-sobre-la-inflamacion-y-carcinogenesis-intestinal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/papel-del-receptor-endovanilloide-trpv-1-sobre-la-inflamacion-y-carcinogenesis-intestinal\/","title":{"rendered":"Papel del receptor endovanilloide trpv-1 sobre la inflamacion y carcinogenesis intestinal."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Amaya Garcia De Vinuesa Antu\u00f1ano <\/strong><\/h2>\n<p>Papel del receptor endovanilloide trpv-1 sobre la inflamaci\u00f3n y carcinog\u00e9nesis intestinal. la conexi\u00f3n entre la inflamaci\u00f3n y el c\u00e1ncer ha sido claramente demostrada y la inflamaci\u00f3n cr\u00f3nica subyacente puede ser especialmente relevante en la carcinog\u00e9nesis gastrointestinal (gi), particularmente en el c\u00e1ncer asociado a colitis (cac). La neuroinflamaci\u00f3n es uno de los ejes fundamentales en la patog\u00e9nesis de la inflamaci\u00f3n en el colon y crecientes evidencias indican que el canal trpv-1 juega un papel crucial en la fisiopatolog\u00eda de la enfermedad inflamatoria intestinal, la cual predispone al desarrollo de c\u00e1ncer de colon. No obstante, la relaci\u00f3n entre la neuroinflamaci\u00f3n y la carcinog\u00e9nesis en colon es aun desconocida. Trpv-1 se expresa en neuronas aferentes en el colon distal y es activado por calor y est\u00edmulos nocivos, por endocannabinoides tales como la anandamida y por vanilloides ex\u00f3genos como la capsaicina. Una de las funciones principales de trpv-1 es transmitir la sensaci\u00f3n de dolor al sistema nervioso central para inducir una respuesta defensiva y por consiguiente se est\u00e1n desarrolando antagonistas espec\u00edficos de trpv-1 como nuevas drogas analg\u00e9sicas. A pesar de esto, los receptores nociceptivos tambi\u00e9n est\u00e1n involucrados en la liberaci\u00f3n de neurop\u00e9ptidos tanto pro- como anti-inflamatorios siendo el equilibrio entre ambos neurop\u00e9ptidos lo que determina el grado de inflamaci\u00f3n. utilizando un modelo consolidado de c\u00e1ncer asociado a colitis hemos encontrado que los ratones carentes de trpv-1 desarrollaron una mayor incidencia y n\u00famero de tumores en el colon distal, con una infiltraci\u00f3n de c\u00e9lulas inflamatorias aumentada y una expresi\u00f3n exacerbada de citoquinas  como la il-6 y la il-11 as\u00ed como una activaci\u00f3n de las rutas de nfb y stat3. Tambi\u00e9n encontramos que la expresi\u00f3n de los neurop\u00e9ptidos vip y pacap est\u00e1 alterada en ratones trpv-1-\/-, y la falta de tales neurop\u00e9ptidos podr\u00eda contribuir a promover un microambiente pro-inflamatorio local. Estos resultados indican que trpv-1 ejerce un papel protector en la inflamaci\u00f3n y progresi\u00f3n tumoral en el colon distal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del receptor endovanilloide trpv-1 sobre la inflamacion y carcinogenesis intestinal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del receptor endovanilloide trpv-1 sobre la inflamacion y carcinogenesis intestinal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Amaya Garcia De Vinuesa Antu\u00f1ano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/02\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Mu\u00f1oz Blanco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Perez jimenez <\/li>\n<li>rocio Sancho zapatero (vocal)<\/li>\n<li>Antonio  vicente Ferrer montiel (vocal)<\/li>\n<li>Manuel Guzm\u00e1n pastor (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Amaya Garcia De Vinuesa Antu\u00f1ano Papel del receptor endovanilloide trpv-1 sobre la inflamaci\u00f3n y carcinog\u00e9nesis intestinal. la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[115,973],"tags":[214973,40714,1979,1613,39707,155622],"class_list":["post-106915","post","type-post","status-publish","format-standard","hentry","category-bioquimica-molecular","category-cordoba","tag-amaya-garcia-de-vinuesa-antunano","tag-antonio-vicente-ferrer-montiel","tag-eduardo-munoz-blanco","tag-francisco-perez-jimenez","tag-manuel-guzman-pastor","tag-rocio-sancho-zapatero"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/106915","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=106915"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/106915\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=106915"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=106915"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=106915"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}