{"id":106921,"date":"2018-03-11T10:31:05","date_gmt":"2018-03-11T10:31:05","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/metalloproteinase-10mmp-10-a-new-link-between-inflammation-and-thrombosis\/"},"modified":"2018-03-11T10:31:05","modified_gmt":"2018-03-11T10:31:05","slug":"metalloproteinase-10mmp-10-a-new-link-between-inflammation-and-thrombosis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/metalloproteinase-10mmp-10-a-new-link-between-inflammation-and-thrombosis\/","title":{"rendered":"Metalloproteinase 10(mmp-10): a new link between inflammation and thrombosis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sara Mart\u00ednez De Lizarrondo Iriarte <\/strong><\/h2>\n<p>We have explored the role of metalloproteinase-10 (mmp-10) or stromelysin-2 in studies in vitro and in vivo and its possible association with thrombotic events. in vitro studies demonstrated that proinflammatory and prothrombotic stimuli, as thrombin and cd40l up-regulate endothelial mmp-10 expression. We described for the first time the synergistic effect of both stimuli on mmp-10 production via par-1-mediated mechanism, and identified the activation of mapk pathways implicated. in vivo studies indicated that thrombin and cd40l co-administration induce vascular expression of mmp-10 in wild-type mice.  we have measured circulating mmp-10 levels in patients with clinical conditions characterized by enhanced thrombin generation. In these clinical settings, a significant increase in mmp-10 levels was found. These findings point out mmp-10 as a novel biomarker for cardiovascular disorders. finally, we observed a significative increment on endothelial microparticle generation after thrombin\/cd40l stimulation. We also demonstrated that these particles harbored mmp-10 activity, which could be regarded as facilitators of endogenous fibrinolysis in conditions characterized by excessive thrombin generation. in summary, these findings reveal a novel interaction between thrombin and cd40l signaling pathways, and establish a new link between inflammation and thrombosis involving mmp-10, which may have relevant pathophysiological and therapeutic implications.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Metalloproteinase 10(mmp-10): a new link between inflammation and thrombosis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Metalloproteinase 10(mmp-10): a new link between inflammation and thrombosis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sara Mart\u00ednez De Lizarrondo Iriarte <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/02\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Paramo Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: mat\u00edas Antonio \u00e1vila zaragoz\u00e1 <\/li>\n<li>Jos\u00e9 Mar\u00eda Mart\u00ednez gonz\u00e1lez (vocal)<\/li>\n<li>joan carles Reverter (vocal)<\/li>\n<li>eduardo Angles-cano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sara Mart\u00ednez De Lizarrondo Iriarte We have explored the role of metalloproteinase-10 (mmp-10) or stromelysin-2 in studies [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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