{"id":106993,"date":"2018-03-11T10:31:10","date_gmt":"2018-03-11T10:31:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-clorhidrato-de-tiaprida-sobre-el-metabolismo-oxidativo-de-cerebro-de-rata-ain-vitroa\/"},"modified":"2018-03-11T10:31:10","modified_gmt":"2018-03-11T10:31:10","slug":"efecto-del-clorhidrato-de-tiaprida-sobre-el-metabolismo-oxidativo-de-cerebro-de-rata-ain-vitroa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacologia\/efecto-del-clorhidrato-de-tiaprida-sobre-el-metabolismo-oxidativo-de-cerebro-de-rata-ain-vitroa\/","title":{"rendered":"Efecto del clorhidrato de tiaprida sobre el metabolismo oxidativo de cerebro de rata \u00c2\u00bfin vitro\u00c2\u00bf"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Ramon Torrecilla Garcia-ripoll <\/strong><\/h2>\n<p>El clorhidrato de tiaprida es una benzamida u ortopramida con efecto neurol\u00e9ptico at\u00edpico. En el presente trabajo se estudia el efecto del clorhidrato de tiaprida sobre el consumo de ox\u00edgeno, glucosa, fosforilaci\u00f3n oxidativa mitocondrial, actividad atpasa y la interacci\u00f3n con diversos neurotransmisores en preparaciones de cortes de corteza de rata \u00abin vitro\u00bb.   en relaci\u00f3n con el material y metodos, se determin\u00f3 el consumo de ox\u00edgeno en cortes, homogeneizados y mitocondrias de cerebro de rata \u00abin vitro\u00bb mediante t\u00e9cnica manom\u00e9trica. La actividad atpasa se determin\u00f3 estimando el fosfato inorg\u00e1nico liberado a partir del adenos\u00edn-trifosfato (atp) en ausencia y en presencia de ouaba\u00edna. Se determin\u00f3 el consumo de glucosa mediante el proceder de la glucosa-oxidasa y tambi\u00e9n se estudi\u00f3 la fosforilaci\u00f3n oxidativa mitocondrial. Para el estudio de las interacciones con los neurotransmisores se recurri\u00f3 a los cortes de cortaza cerebral de rata \u00abin vitro\u00bb. Se determin\u00f3 el valor de la concentraci\u00f3n inbitoria50 cuando el antagonismo era de tipo no competitivo.  el clorhidrato de tiaprida a las concentraciones  de 10-3, 10-4 y 10-5m  disminuye el consumo de ox\u00edgeno de homogeneizados de cerebro de rata \u00abin vitro\u00bb, no desacopla la fosforilaci\u00f3n oxidativa mitocondrial, no modifica el consumo de ox\u00edgeno y de glucosa de cortes de cerebro de rata \u00abin vitro\u00bb incubados en soluci\u00f3n de krebs-ringer fosfato normal, no inhibe la actividad atpasa de membrana sodio-potasio dependiente, ni la actividad atpasa no sensible a ouaba\u00edna.   el clorhidrato de tiaprida a la concentraci\u00f3n de 10-6m antagoniza el incremento de consumo de ox\u00edgeno inducido por la dopamina en cortes de cerebro de rata \u00abin vitro\u00bb incubados en soluci\u00f3n de krebs-ringer fosfato ph 7.4 con glucosa 10 mm, siendo este antagonismo de tipo no competitivo. El clorhidrato de tiaprida no modifica los efectos de histamina y serotonina sobre el consumo de ox\u00edgeno de cortes de cerebro de rata.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto del clorhidrato de tiaprida sobre el metabolismo oxidativo de cerebro de rata \u00c2\u00bfin vitro\u00c2\u00bf<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto del clorhidrato de tiaprida sobre el metabolismo oxidativo de cerebro de rata \u00c2\u00bfin vitro\u00c2\u00bf <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Ramon Torrecilla Garcia-ripoll <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/02\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ernesto Fern\u00e1ndez Del Busto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Casis saenz <\/li>\n<li>Jes\u00fas \u00e1ngel Seco calvo (vocal)<\/li>\n<li>alfonso Carvajal Garc\u00eda-pando (vocal)<\/li>\n<li>alfonso Velasco martin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Ramon Torrecilla Garcia-ripoll El clorhidrato de tiaprida es una benzamida u ortopramida con efecto neurol\u00e9ptico at\u00edpico. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[957,12909],"tags":[12802,12654,25396,72718,215091,13402],"class_list":["post-106993","post","type-post","status-publish","format-standard","hentry","category-farmacologia","category-pais-vasco-euskal-herriko-unibertsitatea","tag-alfonso-carvajal-garcia-pando","tag-alfonso-velasco-martin","tag-ernesto-fernandez-del-busto","tag-jesus-angel-seco-calvo","tag-juan-ramon-torrecilla-garcia-ripoll","tag-luis-casis-saenz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/106993","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=106993"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/106993\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=106993"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=106993"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=106993"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}