{"id":107105,"date":"2011-01-03T00:00:00","date_gmt":"2011-01-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-expresion-del-gen-homeodominio-alx3-y-sus-implicaciones-en-la-generacion-de-malformaciones-congenitas-asociadas-a-la-embriopata%c2%ada-diabetica\/"},"modified":"2011-01-03T00:00:00","modified_gmt":"2011-01-03T00:00:00","slug":"regulacion-de-la-expresion-del-gen-homeodominio-alx3-y-sus-implicaciones-en-la-generacion-de-malformaciones-congenitas-asociadas-a-la-embriopata%c2%ada-diabetica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-expresion-del-gen-homeodominio-alx3-y-sus-implicaciones-en-la-generacion-de-malformaciones-congenitas-asociadas-a-la-embriopata%c2%ada-diabetica\/","title":{"rendered":"Regulacion de la expresi\u00f3n del gen homeodominio alx3 y sus implicaciones en la generaci\u00f3n de malformaciones cong\u00e9nitas asociadas a la embriopat\u00edadiab\u00e9tica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Patricia Garcia Sanz <\/strong><\/h2>\n<p>Alx3\u00c2\u00a0 es\u00c2\u00a0 un\u00c2\u00a0 gen\u00c2\u00a0 tipo\u00c2\u00a0 homeodominio\u00c2\u00a0 de\u00c2\u00a0 la\u00c2\u00a0 familia\u00c2\u00a0 aristaless\u00c2\u00a0 que\u00c2\u00a0 se\u00c2\u00a0 expresa\u00c2\u00a0 durante\u00c2\u00a0el\u00c2\u00a0desarrollo\u00c2\u00a0en\u00c2\u00a0mes\u00e9nquima\u00c2\u00a0craneal\u00c2\u00a0y\u00c2\u00a0participa\u00c2\u00a0en\u00c2\u00a0la\u00c2\u00a0regulaci\u00f3n\u00c2\u00a0del\u00c2\u00a0cierre\u00c2\u00a0 del\u00c2\u00a0tubo\u00c2\u00a0neural.\u00c2\u00a0una\u00c2\u00a0proporci\u00f3n\u00c2\u00a0de\u00c2\u00a0los\u00c2\u00a0embriones\u00c2\u00a0de\u00c2\u00a0rat\u00f3n\u00c2\u00a0deficientes\u00c2\u00a0en\u00c2\u00a0alx3,\u00c2\u00a0muestran\u00c2\u00a0 un\u00c2\u00a0 defecto\u00c2\u00a0 en\u00c2\u00a0 el\u00c2\u00a0 cierre\u00c2\u00a0 de\u00c2\u00a0 esta\u00c2\u00a0 estructura\u00c2\u00a0 durante\u00c2\u00a0 el\u00c2\u00a0 desarrollo\u00c2\u00a0 embrionario.\u00c2\u00a0 en\u00c2\u00a0 la\u00c2\u00a0 presente\u00c2\u00a0 tesis\u00c2\u00a0 \u00c2\u00a0 hemos\u00c2\u00a0 demostrado\u00c2\u00a0 que\u00c2\u00a0 este\u00c2\u00a0 defecto\u00c2\u00a0 se\u00c2\u00a0 asocia\u00c2\u00a0 a\u00c2\u00a0 un\u00c2\u00a0 incremento\u00c2\u00a0 en\u00c2\u00a0 el\u00c2\u00a0 n\u00famero\u00c2\u00a0 de\u00c2\u00a0 c\u00e9lulas\u00c2\u00a0apopt\u00f3ticas\u00c2\u00a0en\u00c2\u00a0la\u00c2\u00a0 regi\u00f3n\u00c2\u00a0anterior\u00c2\u00a0 del\u00c2\u00a0mes\u00e9nquima\u00c2\u00a0 craneofacial que\u00c2\u00a0 contribuye\u00c2\u00a0 a\u00c2\u00a0 que\u00c2\u00a0 exista\u00c2\u00a0 una\u00c2\u00a0 disminuci\u00f3n\u00c2\u00a0 significativa\u00c2\u00a0 de\u00c2\u00a0 la\u00c2\u00a0 densidad\u00c2\u00a0 celular. La\u00c2\u00a0 administraci\u00f3n\u00c2\u00a0 de\u00c2\u00a0 \u00e1cido\u00c2\u00a0 f\u00f3lico\u00c2\u00a0 durante\u00c2\u00a0 el\u00c2\u00a0 periodo\u00c2\u00a0 periconcepcional\u00c2\u00a0 disminuye\u00c2\u00a0la\u00c2\u00a0 incidencia\u00c2\u00a0 de\u00c2\u00a0 este\u00c2\u00a0 tipo\u00c2\u00a0 de\u00c2\u00a0 malformaciones\u00c2\u00a0 cong\u00e9nitas,\u00c2\u00a0 pero\u00c2\u00a0 se\u00c2\u00a0 desconoce\u00c2\u00a0 el\u00c2\u00a0 mecanismo\u00c2\u00a0por\u00c2\u00a0el\u00c2\u00a0cual\u00c2\u00a0ejerce\u00c2\u00a0este\u00c2\u00a0efecto.\u00c2\u00a0los\u00c2\u00a0resultados\u00c2\u00a0de\u00c2\u00a0esta\u00c2\u00a0tesis demuestran\u00c2\u00a0 que\u00c2\u00a0 la\u00c2\u00a0 expresi\u00f3n\u00c2\u00a0 de\u00c2\u00a0 alx3 tambi\u00e9n\u00c2\u00a0 es\u00c2\u00a0 dependiente\u00c2\u00a0 de\u00c2\u00a0 la\u00c2\u00a0 disponibilidad\u00c2\u00a0 del\u00c2\u00a0 \u00e1cido\u00c2\u00a0 f\u00f3lico\u00c2\u00a0in\u00c2\u00a0vivo. hemos\u00c2\u00a0iniciado\u00c2\u00a0estudios\u00c2\u00a0dise\u00f1ados\u00c2\u00a0para\u00c2\u00a0identificar\u00c2\u00a0elementos\u00c2\u00a0reguladores\u00c2\u00a0 en\u00c2\u00a0el\u00c2\u00a0promotor\u00c2\u00a0de\u00c2\u00a0alx3\u00c2\u00a0que\u00c2\u00a0participan\u00c2\u00a0en\u00c2\u00a0el\u00c2\u00a0control\u00c2\u00a0de\u00c2\u00a0su\u00c2\u00a0expresi\u00f3n.\u00c2\u00a0estos\u00c2\u00a0estudios\u00c2\u00a0 han\u00c2\u00a0 conducido\u00c2\u00a0 al\u00c2\u00a0 descubrimiento\u00c2\u00a0 de\u00c2\u00a0 elementos\u00c2\u00a0 que\u00c2\u00a0 reconocen\u00c2\u00a0 factores\u00c2\u00a0 de\u00c2\u00a0 transcripci\u00f3n\u00c2\u00a0de\u00c2\u00a0 tipo\u00c2\u00a0bhlh.\u00c2\u00a0hemos\u00c2\u00a0demostrado\u00c2\u00a0que\u00c2\u00a0los\u00c2\u00a0 factores\u00c2\u00a0de\u00c2\u00a0 transcripci\u00f3n twist,\u00c2\u00a0e47,\u00c2\u00a0usf1\u00c2\u00a0y\u00c2\u00a0usf2\u00c2\u00a0cooperan\u00c2\u00a0en\u00c2\u00a0la\u00c2\u00a0regulaci\u00f3n\u00c2\u00a0transcripcional\u00c2\u00a0del\u00c2\u00a0gen\u00c2\u00a0alx3\u00c2\u00a0a\u00c2\u00a0 trav\u00e9s\u00c2\u00a0de\u00c2\u00a0su\u00c2\u00a0uni\u00f3n\u00c2\u00a0a\u00c2\u00a0dos\u00c2\u00a0cajas\u00c2\u00a0e\u00c2\u00a0situadas\u00c2\u00a0en\u00c2\u00a0la\u00c2\u00a0regi\u00f3n\u00c2\u00a0proximal\u00c2\u00a0del\u00c2\u00a0promotor. por\u00c2\u00a0otro\u00c2\u00a0lado,\u00c2\u00a0en\u00c2\u00a0esta\u00c2\u00a0tesis\u00c2\u00a0hemos\u00c2\u00a0demostrado\u00c2\u00a0que\u00c2\u00a0la\u00c2\u00a0deficiencia\u00c2\u00a0de\u00c2\u00a0alx3 constituye\u00c2\u00a0 un\u00c2\u00a0 factor\u00c2\u00a0 de\u00c2\u00a0 riesgo\u00c2\u00a0 para\u00c2\u00a0 la\u00c2\u00a0 aparici\u00f3n\u00c2\u00a0 de\u00c2\u00a0 malformaciones\u00c2\u00a0 cong\u00e9nitas\u00c2\u00a0 durante\u00c2\u00a0 hiperglucemia\u00c2\u00a0 gestacional.\u00c2\u00a0alx3\u00c2\u00a0 participa\u00c2\u00a0 en\u00c2\u00a0 los\u00c2\u00a0 mecanismos\u00c2\u00a0 de\u00c2\u00a0 defensa\u00c2\u00a0 frente\u00c2\u00a0el\u00c2\u00a0estr\u00e9s\u00c2\u00a0oxidativo\u00c2\u00a0alterados\u00c2\u00a0durante\u00c2\u00a0la\u00c2\u00a0embriopat\u00eda\u00c2\u00a0diab\u00e9tica.\u00c2\u00a0el\u00c2\u00a0incremento de\u00c2\u00a0 la\u00c2\u00a0 vulnerabilidad\u00c2\u00a0 embrionaria\u00c2\u00a0 a\u00c2\u00a0 la\u00c2\u00a0 hiperglucemia\u00c2\u00a0 de\u00c2\u00a0 origen\u00c2\u00a0 materno\u00c2\u00a0 como\u00c2\u00a0 consecuencia\u00c2\u00a0de\u00c2\u00a0la\u00c2\u00a0carencia\u00c2\u00a0de\u00c2\u00a0alx3\u00c2\u00a0se\u00c2\u00a0asocia\u00c2\u00a0a\u00c2\u00a0un\u00c2\u00a0d\u00e9ficit\u00c2\u00a0relativo\u00c2\u00a0de\u00c2\u00a0la\u00c2\u00a0expresi\u00f3n\u00c2\u00a0 de\u00c2\u00a0 genes\u00c2\u00a0 que\u00c2\u00a0 codifican\u00c2\u00a0 factores\u00c2\u00a0 de\u00c2\u00a0 transcripci\u00f3n\u00c2\u00a0 y\u00c2\u00a0 mol\u00e9culas\u00c2\u00a0 de\u00c2\u00a0 se\u00f1alizaci\u00f3n\u00c2\u00a0 extracelulares\u00c2\u00a0importantes\u00c2\u00a0 para\u00c2\u00a0 el\u00c2\u00a0 desarrollo\u00c2\u00a0 embrionario.\u00c2\u00a0 adem\u00e1s,\u00c2\u00a0la\u00c2\u00a0 expresi\u00f3n\u00c2\u00a0 de\u00c2\u00a0alx3\u00c2\u00a0es\u00c2\u00a0necesaria\u00c2\u00a0para\u00c2\u00a0que\u00c2\u00a0el\u00c2\u00a0\u00e1cido\u00c2\u00a0f\u00f3lico\u00c2\u00a0lleve\u00c2\u00a0a\u00c2\u00a0cabo\u00c2\u00a0su\u00c2\u00a0papel\u00c2\u00a0protector\u00c2\u00a0contra\u00c2\u00a0 la\u00c2\u00a0 aparici\u00f3n\u00c2\u00a0 de\u00c2\u00a0 malformaciones\u00c2\u00a0 cong\u00e9nitas\u00c2\u00a0 asociadas\u00c2\u00a0 a\u00c2\u00a0 la\u00c2\u00a0 hiperglucemia\u00c2\u00a0 gestacional.\u00c2\u00a0 ello\u00c2\u00a0 indica\u00c2\u00a0 que\u00c2\u00a0 alx3\u00c2\u00a0 forma\u00c2\u00a0 parte\u00c2\u00a0 del\u00c2\u00a0 mecanismo\u00c2\u00a0 de\u00c2\u00a0 acci\u00f3n\u00c2\u00a0 de\u00c2\u00a0 esta\u00c2\u00a0 vitamina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulacion de la expresi\u00f3n del gen homeodominio alx3 y sus implicaciones en la generaci\u00f3n de malformaciones cong\u00e9nitas asociadas a la embriopat\u00edadiab\u00e9tica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulacion de la expresi\u00f3n del gen homeodominio alx3 y sus implicaciones en la generaci\u00f3n de malformaciones cong\u00e9nitas asociadas a la embriopat\u00edadiab\u00e9tica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Patricia Garcia Sanz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/03\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mario Vallejo Fern\u00e1ndez De La Reguera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Bl\u00e1zquez fern\u00e1ndez <\/li>\n<li>\u00e1ngela Mar\u00eda Mart\u00ednez valverde (vocal)<\/li>\n<li>Jorge Ferrer marrades (vocal)<\/li>\n<li>eduardo Dom\u00ednguez del toro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Patricia Garcia Sanz Alx3\u00c2\u00a0 es\u00c2\u00a0 un\u00c2\u00a0 gen\u00c2\u00a0 tipo\u00c2\u00a0 homeodominio\u00c2\u00a0 de\u00c2\u00a0 la\u00c2\u00a0 familia\u00c2\u00a0 aristaless\u00c2\u00a0 que\u00c2\u00a0 se\u00c2\u00a0 expresa\u00c2\u00a0 durante\u00c2\u00a0el\u00c2\u00a0desarrollo\u00c2\u00a0en\u00c2\u00a0mes\u00e9nquima\u00c2\u00a0craneal\u00c2\u00a0y\u00c2\u00a0participa\u00c2\u00a0en\u00c2\u00a0la\u00c2\u00a0regulaci\u00f3n\u00c2\u00a0del\u00c2\u00a0cierre\u00c2\u00a0 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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