{"id":10722,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1996\/01\/01\/aciclonucleosidos-y-analogos-de-nucleosidos-derivados-de-heteroaldehidos-y-sustancias-relacionables-con-actividad-antitumoral\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"aciclonucleosidos-y-analogos-de-nucleosidos-derivados-de-heteroaldehidos-y-sustancias-relacionables-con-actividad-antitumoral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/aciclonucleosidos-y-analogos-de-nucleosidos-derivados-de-heteroaldehidos-y-sustancias-relacionables-con-actividad-antitumoral\/","title":{"rendered":"Aciclonucleosidos y analogos de nucleosidos, derivados de heteroaldehidos y sustancias relacionables, con actividad antitumoral."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Antonio Gomez Vidal <\/strong><\/h2>\n<p>Las moleculas obejtivo de esta memoria se han obtenido mediante modificacion quimica de la estructura 1-(2-(hidroxietoxi)-1-isopropoxi)-5-fluorouracilo. Esta molecula, cabeza de serie, presenta una actividad frente ala linea celular hep-2, dos veces superior a la observada para el 5-fluorouracilo. Se han sintetizado 20 nuevos aciclonucleosidos y 3 analogos de nucleo-sidos con estructura septanoide, con los que se han realizado ensayos \u00abin vitro\u00bb de inhibicion del crecimiento frente a las lineas tumorales hep-2 y ht-29, asi como estudios de diferenciacion celular en la linea celular de rabdomiosarcoma humano.  la estructura que presento una mayor actividad frente a hep-2 fue el 1-1(-ciclopentoxi-2-(hidroxietoxi)etil)- 5-fluoruracilo (18m) y el compuesto mas activo frente a ht-29 fue el 1-(3-clorometil-1, 4-dioxepano-5- -il)-5-fluorouracilo (30m)<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aciclonucleosidos y analogos de nucleosidos, derivados de heteroaldehidos y sustancias relacionables, con actividad antitumoral.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aciclonucleosidos y analogos de nucleosidos, derivados de heteroaldehidos y sustancias relacionables, con actividad antitumoral. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Antonio Gomez Vidal <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Espinosa \u00fabeda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Vicente Sinisterra Gago <\/li>\n<li>Antonia Aranega Jimenez (vocal)<\/li>\n<li>Giuseppe Ronsisvalle (vocal)<\/li>\n<li>Miguel Fernandez Bra\u00f1a (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Antonio Gomez Vidal Las moleculas obejtivo de esta memoria se han obtenido mediante modificacion quimica de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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