{"id":107326,"date":"2011-11-03T00:00:00","date_gmt":"2011-11-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-melatonina-sobre-la-apoptosis-inducida-por-especies-reactivas-de-oxa%c2%adgeno-y-senal-de-calcio-en-la-la%c2%adnea-celular-leucemica-humana-hl-60\/"},"modified":"2011-11-03T00:00:00","modified_gmt":"2011-11-03T00:00:00","slug":"efecto-de-la-melatonina-sobre-la-apoptosis-inducida-por-especies-reactivas-de-oxa%c2%adgeno-y-senal-de-calcio-en-la-la%c2%adnea-celular-leucemica-humana-hl-60","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/fisiologia-humana\/efecto-de-la-melatonina-sobre-la-apoptosis-inducida-por-especies-reactivas-de-oxa%c2%adgeno-y-senal-de-calcio-en-la-la%c2%adnea-celular-leucemica-humana-hl-60\/","title":{"rendered":"Efecto de la melatonina sobre la apoptosis inducida por especies reactivas de ox\u00edgeno y se\u00f1al de calcio en la l\u00ednea celular leuc\u00e9mica humana hl-60."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ignacio Bejarano Hernando <\/strong><\/h2>\n<p>Analizando conjuntamente los resultados obtenidos en esta tesis doctoral conclu\u00edmos:  1.\tLa melatonina induce una activaci\u00f3n tiempo dependiente de las caspasas 3 y 9 en c\u00e9lulas humanas hl-60. Este efecto estimulante de la melatonina sobre la actividad caspasa fue acompa\u00f1ado por una despolarizaci\u00f3n mitocondrial y por la apertura del poro de permeabilidad transitoria de la mitocondria, aumentando as\u00ed la muerte de las c\u00e9lulas hl-60 por apoptosis. 2.\tLa melatonina muestra una acci\u00f3n prooxidante, que se traduce en un aumento de los niveles de ero intracelulares en c\u00e9lulas leuc\u00e9micas. La actividad prooxidante de la melatonina est\u00e1 directamente relacionada con su citotoxicidad y efectos proapopt\u00f3ticos en c\u00e9lulas tumorales de origen hematopoy\u00e9tico. 3.\tLa apoptosis inducida por h2o2 y tapsigargina es dependiente de los incrementos en la [ca2+]c. El vaciamiento de los dep\u00f3sitos intracelulares de calcio inducidos por h2o2 y tapsigargina inducen sobrecarga de calcio intramitocondrial, que genera la apertura del poro de permeabilidad transitoria de la mitocondria, aumentando la actividad caspasa, externalizando fosfatidilserina, activando prote\u00ednas proapopt\u00f3ticas y fragmentando el adn. 4.\tA diferencia de lo que ocurre en c\u00e9lulas no tumorales, la melatonina aumenta los acontecimientos apopt\u00f3ticos inducidos por h2o2 en c\u00e9lulas leuc\u00e9micas hl-60. En esta l\u00ednea celular tumoral, y bajo condiciones de severo estr\u00e9s oxidativo inducido por el agente oxidante h2o2, la melatonina presenta un comportamiento prooxidante y proapopt\u00f3ticos en c\u00e9lulas leuc\u00e9micas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la melatonina sobre la apoptosis inducida por especies reactivas de ox\u00edgeno y se\u00f1al de calcio en la l\u00ednea celular leuc\u00e9mica humana hl-60.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la melatonina sobre la apoptosis inducida por especies reactivas de ox\u00edgeno y se\u00f1al de calcio en la l\u00ednea celular leuc\u00e9mica humana hl-60. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ignacio Bejarano Hernando <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/03\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Pariente Llanos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Emilio jose Sanchez barcelo <\/li>\n<li>vladimir Gogvadze (vocal)<\/li>\n<li>Manuel Antonio Manso mart\u00edn (vocal)<\/li>\n<li>carmen Barriga ibars (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ignacio Bejarano Hernando Analizando conjuntamente los resultados obtenidos en esta tesis doctoral conclu\u00edmos: 1. La melatonina induce [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,949,817],"tags":[23981,10676,215621,33406,62754,215622],"class_list":["post-107326","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-extremadura","category-fisiologia-humana","tag-carmen-barriga-ibars","tag-emilio-jose-sanchez-barcelo","tag-ignacio-bejarano-hernando","tag-jose-antonio-pariente-llanos","tag-manuel-antonio-manso-martin","tag-vladimir-gogvadze"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/107326","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=107326"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/107326\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=107326"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=107326"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=107326"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}