{"id":10752,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1996\/01\/01\/quimioterapia-in-vitro-frente-a-cryptosporidium\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"quimioterapia-in-vitro-frente-a-cryptosporidium","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/quimioterapia-in-vitro-frente-a-cryptosporidium\/","title":{"rendered":"Quimioterapia in vitro frente a cryptosporidium."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Khalifa Latifa <\/strong><\/h2>\n<p>La criptosporidiosis es una zoonosis, de gran importancia en la poblacion infantil y en la inmunodepresion, frente a la que no existe una terapia especifica.Partiendo del cultivo de c.Parvum sobre celulas mdck, se ha llevado a cabo la evaluacion de la actividad de distintos farmacos in vitro frente a cryptosporidium.Los ooquistes de cryptosporidium se obtienen inicialmente de heces de terneras con parasitacion espontanea y se someten a un proceso de concentracion y purificacion segun metodolog\u00eda propia, y a digestion para liberar los esporozoitos. La interaccion parasito-celula se lleva a cabo en proporcion 1:1 durante 12 horas. La metodolog\u00eda empleada conduce a un porcentaje de parasitacion de un 8% siendo las distintas formas de desarrollo del parasito visualizables a microscopia optica, mediante tecnicas especiales de tincion. La accion de los distintos farmacos sobre el sistema parasito-celula se ensayaron a distintos tiempos, tanto en la fase de interaccion, (accion preventiva), como en cultivos establecidos, (hasta 72 horas), (accion curativa-inhibicion de la merogonia continuada).  asi se realizo un estudio que se centra en:  la determinacion de la actividad in vitro de antiprotozoarios conocidos por su demostrada accion frente a otros coccidios.  la determinacion de la actividad in vitro de antiprotozoarios de nueva sintesis, compuestos acridinicos y sus derivados.  seleccion de los compuestos mas efectivos y estudio de citotoxicidad de estos sobre celulas mdck y de la relacion estructura-actividad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Quimioterapia in vitro frente a cryptosporidium.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Quimioterapia in vitro frente a cryptosporidium. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Khalifa Latifa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Mascar\u00f3 Lazcano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Diego Carlos Guevara Benitez <\/li>\n<li>Antonio Osuna Carrillo De Albornoz (vocal)<\/li>\n<li>Jacques Barbe (vocal)<\/li>\n<li> Molina Molina Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Khalifa Latifa La criptosporidiosis es una zoonosis, de gran importancia en la poblacion infantil y en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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